PRELIMINARY TESTS OF LOCAL HYPERTHERMIA BASED ON INDUCTIVELY HEATED TUMOR BED IMPLANT
Open Access
- 30 December 2017
- journal article
- Published by Kemerovo State University in Science Evolution
- Vol. 2 (2), 15-21
- https://doi.org/10.21603/2500-1418-2017-2-2-15-21
Abstract
Hyperthermia, i.e. tissue heating to a temperature of 39-45°C, is considered to be a very promising technique to increase the sensitivity of tumor cells to ionizing radiation and chemical preparations. At the present time, there are numerous methods for producing hyperthermia with the optimum method dependent on the required volume, depth, and site of heating. This paper presents the results of preliminary theoretical and in vivo confirmation studies of the feasibility of intraoperative local hyperthermia via induction heating of ferromagnetic material within a tumor bed implant that fills a resected tumor cavity. The implant is made during the surgical removal of tumor by mechanically filling the tumor bed with a self-polymerizing silicone paste in which very fine electroconductive ferromagnetic particles are uniformly distributed. Therefore, the implant can accommodate unique characteristics of each patient’s tumor bed. For the laboratory experiments, a prototype induction heating system was used to produce an alternating magnetic field with a frequency of about 100 kHz and a maximum intensity up to 3 kA/m inside an induction coil of inner diameter 35 cm. Experiments were conducted to heat a 2.5 cm diameter spherical implant both in open air and inside the thigh of a living rabbit. The results in both cases are in good agreement with our theoretical estimations. It was established that the temperature gradient near the implant surface decreases with increasing implant size, and for typical size tumor bed implants produces effective hyperthermia to a distance of more than 5 mm from the implant surface. This result provides hope for a decrease in relapse after treatment of malignant tumors using our combination heat plus intraoperative high dose rate local radiotherapy approach. Moreover, the externally coupled implant heating can be combined with local chemotherapy by applying a self-resorbable polymer film containing antineoplastic agents to the surface of the implant.Keywords
This publication has 28 references indexed in Scilit:
- Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the futureCancer Treatment Reviews, 2015
- Selective organ preservation with neo-adjuvant chemotherapy for the treatment of muscle invasive transitional cell carcinoma of the bladderBritish Journal of Cancer, 2015
- Organ preservation in rectal cancer: have all questions been answered?The Lancet Oncology, 2015
- Organ preservation in T4a laryngeal cancer: is transoral laser microsurgery an option?European Archives of Oto-Rhino-Laryngology, 2013
- Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time‐ and temperature‐dependent mannerJournal of Cellular Physiology, 2012
- Thermal Targeting of an Acid-Sensitive Doxorubicin Conjugate of Elastin-like Polypeptide Enhances the Therapeutic Efficacy Compared with the Parent Compound In VivoMolecular Cancer Therapeutics, 2012
- Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant CellsMethods in molecular biology (Clifton, N.J.), 2010
- Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistryRadiotherapy and Oncology, 2008
- Cellular responses to hyperthermia (40–46°C): Cell killing and molecular eventsInternational Journal of Hyperthermia, 2008
- Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the fieldInternational Journal of Hyperthermia, 2006