Association between Intraplaque Hemorrhage and Vascular Remodeling in Carotid Arteries: The Plaque at RISK (PARISK) Study
Open Access
- 3 December 2020
- journal article
- research article
- Published by S. Karger AG in Cerebrovascular Diseases
- Vol. 50 (1), 94-99
- https://doi.org/10.1159/000511935
Abstract
Introduction: Vascular remodeling is a compensatory enlargement of the vessel wall in response to atherosclerotic plaque growth. We aimed to investigate the association between intraplaque hemorrhage (IPH), vascular remodeling, and luminal dimensions in recently symptomatic patients with mild to moderate carotid artery stenosis in which the differences in plaque size were taken into account. Materials and Methods: We assessed vessel dimensions on MRI of the symptomatic carotid artery in 164 patients from the Plaque At RISK study. This study included patients with recent ischemic neurological event and ipsilateral carotid artery stenosis Results: Plaques with IPH had a larger WA (0.56 vs. 0.46 cm2; p < 0.001), a smaller LA (0.17 vs. 0.22 cm2; p = 0.03), and a higher RR (2.0 vs. 1.9; p = 0.03) than plaques without IPH. After adjustment for WA, plaques containing IPH had a smaller LA (B = −0.052, p = 0.01) than plaques without IPH, but the RR was not different. Conclusion: After correcting for plaque size, plaques containing IPH had a smaller LA than plaques without IPH. However, RR was not different.Keywords
This publication has 25 references indexed in Scilit:
- Plaque Vulnerability in Internal Carotid Arteries with Positive RemodelingCerebrovascular Diseases Extra, 2011
- Arterial Remodeling in the Subclinical Carotid Artery DiseaseJACC: Cardiovascular Imaging, 2009
- Reproducibility of Fibrous Cap Status Assessment of Carotid Artery Plaques by Contrast-Enhanced MRIStroke, 2009
- The Impact of Expansive Arterial Remodeling on Clinical Presentation in Carotid Artery Disease: A Multidetector CT Angiography StudyAmerican Journal of Neuroradiology, 2007
- Carotid Intraplaque Hemorrhage Predicts Recurrent Symptoms in Patients With High-Grade Carotid StenosisStroke, 2007
- Atherosclerotic Plaque Progression and Vulnerability to RuptureArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic PlaquesCirculation, 2005
- In vivo detection of hemorrhage in human atherosclerotic plaques with magnetic resonance imagingJournal of Magnetic Resonance Imaging, 2004
- Ischemic Stroke SubtypesStroke, 1999
- Compensatory Enlargement of Human Atherosclerotic Coronary ArteriesThe New England Journal of Medicine, 1987