Electrooxidative B−H Functionalization of nido‐Carboranes
- 29 December 2020
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 60 (14), 7838-7844
- https://doi.org/10.1002/anie.202015299
Abstract
An atom economical method for the direct cage B－H functionalization of nido‐carboranes (7,8‐nido‐C2B9H12‐) has been developed under electrochemical reaction conditions. In this reaction system, anodic oxidation serves as a green alternative for traditional chemical oxidants in the oxidation of nido‐carboranes. No transition metal catalyst is required and different heteroatoms bearing a lone pair are reactive in this transformation. Coupling of nido‐carboranes with thioethers, selenides, tellurides, N‐heterocycles, phosphates, phosphines, arsenides and antimonides all demonstrates high site‐selectivity and efficiency. Importantly, nido‐carboranes can be easily incorporated into drug motifs through this reaction protocol.Keywords
Funding Information
- National Natural Science Foundation of China (21820102004, 21531004, 91961104)
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