Characteristics associated with self-reported medication adherence in persons with psychosis referred to psychosocial rehabilitation centers
- 10 November 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Archiv Fur Psychiatrie Und Nervenkrankheiten
- Vol. 271 (8), 1415-1424
- https://doi.org/10.1007/s00406-020-01207-x
Abstract
The aim of the present study was to explore the characteristics of psychotropic treatment and of psychosocial functioning associated with self-reported medication adherence in persons with psychosis engaged in rehabilitation. The study was performed in the REHABase cohort including persons referred to a French network of psychosocial rehabilitation centers. Treatment adherence was assessed using the Medication Adherence Rating Scale (MARS). The associations between MARS score (categorized as “low” < 7 vs. “high” ≥ 7) and functioning or psychotropic treatment characteristics were explored using multivariate analyses in 326 participants with schizophrenia spectrum disorders. Regarding psychotropic treatment, high anticholinergic load was the only characteristic associated with poor medication adherence (adjusted OR, aOR 1.98, 95% CI 1.07–3.66). Regarding functioning measures, participants with poor medication adherence were more likely to present with lower stage of recovery (aOR 2.38, 95% CI 1.31–4.32), poor quality of life (aOR 2.17, 95% CI 1.27–3.71), mental well-being (aOR 1.68, 95% CI 1.03–2.72) and self-esteem (aOR 1.74, 95% CI 1.05–2.87), and higher internalized stigma (aOR 1.88, 95% CI 1.09–3.23). Self-reported poor medication adherence is a marker of poor functioning in persons with psychosis. The MARS is a quick and simple measure of adherence that may be helpful in clinical and rehabilitation settings to identify persons with specific rehabilitation needs.Funding Information
- Auvergne-Rhône-Alpes Regional Health Agencies.
- Nouvelle-Aquitaine Regional Health Agencies.
This publication has 53 references indexed in Scilit:
- Assessment of adherence to oral antipsychotic medications: What has changed over the past decade?Schizophrenia Research, 2019
- Adherence to Antipsychotic Medication in Bipolar Disorder and Schizophrenic PatientsJournal of Clinical Psychopharmacology, 2016
- Recovery in Psychosis: A Delphi Study With Experts by ExperienceSchizophrenia Bulletin, 2014
- Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategiesWorld Psychiatry, 2013
- Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysisThe Lancet, 2012
- Strategies for Improving Treatment Adherence in Schizophrenia and Schizoaffective DisorderBritish Journal of Psychology, 2010
- Cross-sectional and Longitudinal Relationships Between Insight and Attitudes Toward Medication and Clinical Outcomes in Chronic SchizophreniaSchizophrenia Bulletin, 2008
- Defining and Assessing Adherence to Oral Antipsychotics: A Review of the LiteratureSchizophrenia Bulletin, 2005
- Medication adherence in psychosis: predictors and impact on outcome.A 2‐year follow‐up of first‐admitted subjectsActa Psychiatrica Scandinavica, 2000
- Compliance With Medication Regimens for Mental and Physical DisordersPsychiatric Services, 1998