Multivariate Statistical Approach for Nephrines in Women with Obesity
Open Access
- 5 March 2021
- Vol. 26 (5), 1393
- https://doi.org/10.3390/molecules26051393
Abstract
Catecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis and principal component analysis. The 24-h urine excretion of metanephrine and normetanephrine was investigated in 150 obese women (54 non diabetic without MS, 70 non-diabetic with MS and 26 with type 2 diabetes). The interrelations between carbohydrate disturbances, metabolic syndrome components and stress response hormones were studied. Exploratory data analysis was used to determine different patterns of similarities among the patients. Normetanephrine concentrations were significantly increased in postmenopausal patients and in women with morbid obesity, type 2 diabetes, and hypertension but not with prediabetes. Both metanephrine and normetanephrine levels were positively associated with glucose concentrations one hour after glucose load irrespectively of the insulin levels. The exploratory data analysis showed different risk subgroups among the investigated obese women. The development of predictive tools that include not only traditional metabolic risk factors, but also markers of stress response systems might help for specific risk estimation in obesity patients.Funding Information
- Medical University-Sofia (D125/02.05.2017)
- BSF (KP- 06/ОРR 03-14– 2018)
This publication has 22 references indexed in Scilit:
- One-hour post-load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and HypertensionDiabetic Medicine, 2016
- Plasma Metanephrines Are Associated With Glucose Metabolism in Patients With Essential HypertensionMedicine, 2015
- Cortisol: the villain in Metabolic Syndrome?Revista da Associação Médica Brasileira, 2014
- Neuroadrenergic Dysfunction Along the Diabetes ContinuumDiabetes, 2012
- Harmonizing the Metabolic SyndromeCirculation, 2009
- Stress, Visceral Obesity, and Metabolic ComplicationsAnnals of the New York Academy of Sciences, 2006
- Impact of Carbohydrate-Rich Meals on Plasma Epinephrine Levels: Dysregulation with AgingJournal of Clinical Endocrinology & Metabolism, 2005
- Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong ChineseMetabolism, 2001
- New insights into sympathetic regulation of glucose and fat metabolismDiabetologia, 2000
- Decreased plasma epinephrine concentrations after glucose ingestion in humansMetabolism, 1984