Left Ventricular Hypertrophic Change Indicating Poor Prognosis in Patients With Normal-Flow, Low-Gradient Severe Aortic Stenosis With Preserved Left Ventricular Ejection Fraction
Open Access
- 26 May 2021
- journal article
- research article
- Published by Japanese Circulation Society in Circulation Reports
- Vol. 3 (6), CR-21-0011-353
- https://doi.org/10.1253/circrep.cr-21-0011
Abstract
Background:Risk stratification of normal-flow, low-gradient (NFLG) severe aortic stenosis (SAS) with preserved left ventricular (LV) ejection fraction (EF) remains unclear. Methods and Results:Of 289 consecutive patients diagnosed with SAS by aortic valve area 35 mL/m2, mean pressure gradient 95 mg/m2for males and females, respectively; HR 3.257; 95% CI 1.172–9.050; P=0.024), and tricuspid regurgitation (TR) velocity (HR 2.761; 95% CI 1.246–6.118; P=0.012). Conclusions:The presence of symptoms, LV hypertrophy, and high TR velocity could be reliable prognostic indicators and may require watchful waiting for timely AVR in patients with NFLG-SAS.Keywords
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