Tuberculosis remains a major public health problem, with an estimated 9 million TB incidence cases, 300,000 of which are drug resistant TB cases and resulted in 1.5 million deaths worldwide in 2013. However, only 58% of new cases, TB cases were confirmed bacteriologically using WHO recommended test including the Xpert® MTB/RIF Rapid Diagnosis. The use of GeneXpert in Indonesia has existed since 2014 and has never been evaluated in its utilization, including in the city of Denpasar, namely in Wangaya Hospital as one of the recipients of the GeneXpert pulmonary TB diagnostic aid. The results of this study showed that the results of GeneXpert examination were much higher in the percentage of Positive TB Case Findings compared to microscopic examination so that there is an increase in the number of positive TB cases by 14.3%. The GeneXpert examination succeeded in giving positive results compared to the microscopic results showing negative results, which were sensitive Rifampicin (14.6%) and resistant Rifampicin (2.4%). However, the utilization of TB suspect examination with GeneXpert has not been maximized in increasing the number of TB patients suspected of having TB, in fact, the percentage of positive TB case finding compared to TB suspicion is increasing. Keywords:GeneXpert, rapid diagnosis of tuberculosis, pulmonary tuberculosis ABSTRAK Tuberkulosis (TB) tetap menjadi masalah kesehatan masyarakat yang utama, diperkirakan telah terjadi 9 juta kasus insiden TB, 300.000 di antaranya adalah kasus TB multidrug resistant (TB MDR) dan mengakibatkan 1,5 juta kematian di seluruh dunia pada tahun 2013. Namun, baru 58% dari kasus baru, kasus TB dikonfirmasi secara bakteriologis menggunakan tes yang direkomendasikan oleh WHO termasuk Tes Cepat Molekuler (TCM) GeneXpert® MTB/RIF (Xpert). Pemanfaatan TCM GeneXpert di Indonesia ada sejak 2014 dan belum pernah dilakukan evaluasi dalam pemanfaatannya termasuk di Kota Denpasar yaitu di RSUD Wangaya sebagai salah satu penerima bantuan alat diagnostik TB Paru TCM GeneXpert. Hasil studi menunjukkan bahwa hasil pemeriksaan dengan TCM GeneXpert jauh lebih tinggi persentase penemuan kasus positif TBC dibanding dengan pemeriksaan mikroskopis sehingga terdapat peningkatan jumlah kasus positif TBC sebesar 14,3% di RSUD Wangaya pada tahun 2018. Pemeriksaan TCM GeneXpert berhasil memberikan hasil yang positif di saat hasil pemeriksaan mikroskopis menunjukkan hasil negatif yaitu Rifampisin sensitif (14,6%) dan Rifampisin resisten (2,4%). Pemanfaatan pemeriksaan terduga TB dengan TCM GeneXpert belum maksimal dalam meningkatkan jumlah pemeriksaan pasien terduga TB Paru, walaupun persentase penemuan kasus positif TB dibanding terduga TB meningkat. Kata kunci: Tes cepat molekuler, geneXpert, tuberkulosis paru