The Impact of Mother’s Living Environment Exposure on Genome Damage, Immunological Status, and Sex Hormone Levels in Newborns
Open Access
- 12 May 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 17 (10), 3402
- https://doi.org/10.3390/ijerph17103402
Abstract
Background: The aim of this study was to compare for the first time IL-6 (Interleukin 6), testosterone (T) and estradiol (E) levels, their ratio (E/T), micronucleus (MN), and nuclear bridge (NB) frequency between newborns with regard to their mother’s residency and diet. Our results should enable an assessment of the possible environmental endocrine effects and interaction between biomarkers, pointing to possible associated health risks. Methods: Fifty full-term newborns of both sexes, whose mothers were healthy and not occupationally exposed to any known carcinogen, were analyzed. All of the mothers filled in a detailed questionnaire. Results: The results showed significantly higher levels of E in newborns of mothers with agricultural residency than those born by mothers with urban residency. Significantly, lower levels of E were measured in newborns of mothers who drank milk and carbonated beverages more frequently. Testosterone was significantly higher in boys of mothers with agricultural residency than from mothers with urban residency. Residence and other parameters had no impact on the difference in MN frequency. IL-6 levels were higher in newborns of mothers with agricultural residency. NB levels were significantly associated with E. A significant association between E levels and IL-6 was found. Conclusion: Our results were the first to show a significant impact of the mother’s agricultural residency and diet on their newborns’ sex hormone and IL-6 levels and their association.Funding Information
- European Commission (KK.01.1.1.01.0008)
This publication has 61 references indexed in Scilit:
- Study on the leaching of phthalates from polyethylene terephthalate bottles into mineral waterScience of The Total Environment, 2013
- Estradiol and Progesterone Strongly Inhibit the Innate Immune Response of Mononuclear Cells in NewbornsInfection and Immunity, 2011
- Fetal Exposure to Chlordane and Permethrin Mixtures in Relation to Inflammatory Cytokines and Birth OutcomesEnvironmental Science & Technology, 2011
- Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cellsMutagenesis, 2010
- Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother–newborn pairsEnvironment International, 2010
- Exposure to exogenous estrogen through intake of commercial milk produced from pregnant cowsPediatrics International, 2010
- Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollutionEnvironmental Research, 2009
- Effects of Testosterone, 17β‐Estradiol, and Downstream Estrogens on Cytokine Secretion from Human Leukocytes in the Presence and Absence of CortisolAnnals of the New York Academy of Sciences, 2006
- Spontaneous and induced aneuploidy, considerations which may influence chromosome malsegregationMutation research. Reviews in mutation research, 2002
- Structural specificity of estrogens in the induction of mitotic chromatid non-disjunction in HeLa cellsExperimental Cell Research, 1967