Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going
Open Access
- 16 May 2022
- Vol. 11 (5), 759
- https://doi.org/10.3390/biology11050759
Abstract
Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous preclinical and clinical studies. Over the years, the endothelin system has been found to be critical in the pathogenesis of several cardiovascular diseases, including hypertension, pulmonary arterial hypertension, heart failure, and coronary artery disease. In this review, we summarize the current knowledge on endothelin and its role in cardiovascular diseases. Furthermore, we discuss how endothelin-targeting therapies, such as endothelin receptor antagonists, have been employed to treat cardiovascular diseases with varying degrees of success. Lastly, we provide a glimpse of what could be in store for endothelin-targeting treatment options for cardiovascular diseases in the future.Funding Information
- JSPS KAKENHI (JP22H02774 to N.E.)
This publication has 272 references indexed in Scilit:
- The Interaction of Endothelin-1 and TGF-β1 Mediates Vascular Cell RemodelingPLOS ONE, 2013
- Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in miceJCI Insight, 2013
- Increased Levels of Inflammatory Cytokines and Endothelin-1 in Alveolar Macrophages from Patients with Chronic Heart FailurePLOS ONE, 2012
- Common variant near the endothelin receptor type A ( EDNRA ) gene is associated with intracranial aneurysm riskProceedings of the National Academy of Sciences of the United States of America, 2011
- Cooperative role of ETAand ETBreceptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusionAmerican Journal of Physiology-Renal Physiology, 2010
- Endothelin‐1 gene regulationThe FASEB Journal, 2010
- Association of Left Atrial Endothelin-1 With Atrial Rhythm, Size, and Fibrosis in Patients With Structural Heart DiseaseCirculation: Arrhythmia and Electrophysiology, 2010
- Myocardial Protective Effect of Tezosentan, an Endothelin Receptor Antagonist, for Ischemia-Reperfusion Injury in Experimental Heart Failure ModelsJournal of Korean Medical Science, 2009
- Anatomical Profiling of G Protein-Coupled Receptor ExpressionCell, 2008
- Contrasting Actions of Endothelin ETAand ETBReceptors in Cardiovascular DiseaseAnnual Review of Pharmacology and Toxicology, 2007