Viridistratins A−C, Antimicrobial and Cytotoxic Benzo[j]fluoranthenes from Stromata of Annulohypoxylon viridistratum (Hypoxylaceae, Ascomycota)
Open Access
- 23 May 2020
- journal article
- research article
- Published by MDPI AG in Biomolecules
- Vol. 10 (5), 805
- https://doi.org/10.3390/biom10050805
Abstract
During the course of our search for novel biologically active metabolites from tropical fungi, we are using chemotaxonomic and taxonomic methodology for the preselection of interesting materials. Recently, three previously undescribed benzo[j]fluoranthenes (1−3) together with the known derivatives truncatones A and C (4, 5) were isolated from the stromata of the recently described species Annulohypoxylon viridistratum collected in Thailand. Their chemical structures were elucidated by means of spectral methods, including nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). The new compounds, for which we propose the trivial names viridistratins A−C, exhibited weak-to-moderate antimicrobial and cytotoxic activities in cell-based assays.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (SP1991)
This publication has 28 references indexed in Scilit:
- Synthesis and assembly of fungal melaninApplied Microbiology and Biotechnology, 2011
- Hypoxylonols C–F, Benzo[j]fluoranthenes from Hypoxylon truncatumJournal of Natural Products, 2011
- Hydrophobic substances induce water stress in microbial cellsMicrobial Biotechnology, 2010
- Chapter 3 Fungal Type I Polyketide SynthasesMethods in Enzymology, 2009
- Cytotoxic Benzo[j]fluoranthene Metabolites from Hypoxylon truncatum IFB-18, an Endophyte of Artemisia annuaJournal of Natural Products, 2006
- Molecular phylogeny of Hypoxylon and closely related generaMycologia, 2005
- Cohaerins A and B, azaphilones from the fungus Hypoxylon cohaerens, and comparison of HPLC-based metabolite profiles in Hypoxylon sect. AnnulataPhytochemistry, 2005
- Chemical Constituents of the Ascomycete Daldinia concentricaJournal of Natural Products, 2002
- Hypoxylonols A and B, Novel Reduced Benzo[j]fluoranthene Derivatives from the Mushroom Hypoxylon truncatumJournal of Natural Products, 2002
- Toxicological Profile for Polycyclic Aromatic Hydrocarbons, U.S. Department of Health & Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Washington, D.C., August, 1985Journal of Toxicology- Cutaneous and Ocular Toxicology, 1999