Extra Virgin Olive Oil Protects the Testis and Blood from the Toxicity of Paracetamol (Overdose) in Adult Male Rats
Open Access
- 14 October 2021
- Vol. 10 (10), 1042
- https://doi.org/10.3390/biology10101042
Abstract
Extra virgin olive oil (EVOO) is important in people’s daily diets. Paracetamol is a widely used analgesic and antipyretic drug. The aim of this study is to investigate the protective effect of EVOO against hematotoxicity and testicular toxicity induced by paracetamol overdose in rats. Forty rats were divided into four groups. Group 1 rats were given water (control), Group 2 rats were given oral EVOO daily (2 mL/kg b.wt.), Group 3 rats were given oral paracetamol daily (650 mg/kg b.wt.), and Group 4 rats were given paracetamol and EVOO daily. After 15 days, blood and testis samples were collected for biochemical, histological, and ultrastructural studies. The results show that paracetamol decreased the PCV, Hb, and RBC counts relative to the control, and significantly increased the WBC counts and stab cells in Group 3. A significant decrease in blood testosterone was found in Group 3 compared to the control, while a significant increase in testosterone levels was observed in Group 4 compared to Group 3. Light and electron microscopy showed disorganized seminiferous tubules in Group 3. The testis in Group 4 appeared in normal shape. In conclusion, the results indicate that EVOO protects the testis and blood from paracetamol toxicity and may also increase fertility in male rats.This publication has 25 references indexed in Scilit:
- Mechanisms of Action of Phenolic Compounds in OliveJournal of Dietary Supplements, 2012
- Attenuating effect of Allium ascalonicum L. on paracetamol induced seminal quality impairment in miceJournal of Medicinal Plants Research, 2012
- Characterization of antioxidant olive oil biophenols by spectroscopic methodsJournal of the Science of Food and Agriculture, 2010
- Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-Dichlorophenoxyacetic acid-treated ratsNutrition & Metabolism, 2010
- Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense systemExperimental and Toxicologic Pathology, 2008
- Olive oil and the cardiovascular systemPharmacological Research, 2007
- Dietary patterns: A Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease riskNutrition, Metabolism and Cardiovascular Diseases, 2006
- International conference on the healthy effect of virgin olive oilEuropean Journal of Clinical Investigation, 2005
- Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood culturesNutrition, 2005
- Spectrophotometric and kinetics investigation of the Berthelot reaction for the determination of ammoniaAnalytical Chemistry, 1977