Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence
Open Access
- 1 September 2021
- journal article
- review article
- Published by Taylor & Francis Ltd in Vascular Health and Risk Management
- Vol. ume 17, 591-600
- https://doi.org/10.2147/vhrm.s324112
Abstract
Flavonoids are oral venoactive drugs frequently prescribed to relieve the symptoms of chronic venous disorders (CVD). Among venoactive drugs, diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources; it can also be obtained after conversion of hesperidin extracted from citrus rinds. Micronized purified flavonoid fraction (MPFF) is a preparation that contains mainly diosmin and a small fraction of hesperidin. We performed a state-of-the-art literature review to collect and analyze well-conducted randomized clinical studies comparing diosmin – also called non-micronized or hemisynthetic diosmin – 600 mg a day and MPFF, 1000 mg a day. Three clinical studies met the criteria and were included for this literature review. These clinical studies showed a significant decrease of CVD symptom intensity (up to approximately 50%) and global patient satisfaction after one-to-six-month treatment with diosmin or MPFF, without statistical differences between these two forms of diosmin. Both treatments were well tolerated with few mild adverse drug reactions reported. Overall, based on this literature review, there is no clinical benefit to increase the dose of diosmin beyond 600 mg per day, to use the micronized form, or to add hesperidin, since clinical efficacy on venous symptomatology is achieved with 600 mg per day of pure non-micronized diosmin. This challenges the status of diosmin – 600 mg a day – in guidelines for the management of CVD, which is currently categorized 2C (weak recommendations for use and poor quality of evidence), while the most widely used and assessed preparation MPFF is rated 1B (strong recommendation for use and moderate quality of evidence).Keywords
This publication has 30 references indexed in Scilit:
- Phlebotonics for venous insufficiencyEmergencias, 2016
- Chronic Venous InsufficiencyCirculation, 2014
- Pharmacological Treatment of Primary Chronic Venous Disease: Rationale, Results and Unanswered QuestionsEuropean Journal of Vascular and Endovascular Surgery, 2011
- Phlebotonics for venous insufficiencyPublished by Wiley ,2005
- Revision of the CEAP classification for chronic venous disorders: Consensus statementJournal of Vascular Surgery, 2004
- A Randomised Controlled Trial of Micronised Purified Flavonoid Fraction vs Placebo in Patients with Chronic Venous DiseaseEuropean Journal of Vascular and Endovascular Surgery, 2002
- Comparison of the Absorption of Micronized (Daflon 500® mg) and Nonmicronized 14C‐diosmin Tablets After Oral Administration to Healthy Volunteers by Accelerator Mass Spectrometry and Liquid Scintillation CountingJournal of Pharmaceutical Sciences, 2002
- Chronic venous insufficiency diseaseInternational Journal of Angiology, 1997
- Reporting standards in venous disease: An updateJournal of Vascular Surgery, 1995
- Diosmin‐induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral veinBritish Journal of Pharmacology, 1994