Numerous unresolved issues exist regarding the lithosphere of Antarctica, especially in terms of its fundamental density, temperature, and compositional structure. Estimates of total lithospheric thickness typically involve assumptions on the depth of the Moho discontinuity, which remains ill-constrained in several parts of Antarctica. Recent estimates of the Moho depth from different geophysical methods show significant discrepancies of 10-20 km in large sectors of the continent. While seismological methods suffer from a limited station coverage and ice reverberation, potential field methods, such as gravity studies, are inherently non-unique. By modelling multiple geophysical parameters in a consistent way and accounting for thermodynamically stable mineral phases of rocks as a function of pressure and temperature conditions, we were able to mitigate the detrimental effects of data sparseness while also reducing geophysical inconsistencies and ambiguities. Gravity gradient data from ESA’s satellite mission ‘GOCE’ are used here to constrain the density distribution within the lithosphere in an integrated 3D model of the Antarctic continent. Independent seismic estimates serve as a benchmark for the robustness of our results. Our model derives new estimates of the crustal and the total lithospheric thickness of Antarctica.Based on our new 3D lithospheric model, we investigate the feasibility of a mantle plume beneath parts of West Antarctica, which has been inferred from previous geochemistry, seismology, and glacial isostatic adjustment studies. The impact of thermal anomalies, simulating ponded plume material, on different geophysical parameters, such as geothermal heat flux, seismic velocities, mineral phase transition changes, gravity, and topographic elevation are modelled for both Marie Byrd Land and Ross Island, two key candidate sites for putative plumes. Combined interpretation of the results is performed together with current understanding of geodynamic processes, such as locations of the LLVPs at the core-mantle boundary, representing potential ‘cradles’ for plumes.Our results suggest that a deep-rooted mantle plume is unlikely beneath West Antarctica. However, the observed low seismic velocity zones could still correspond to proposed hot upper mantle zones characterised by lower viscosity. Alternative/additional explanations, such compositional effects and water content as causes for the seismic anomalies must also be further evaluated to better assess their effects on mantle viscosities. This is particularly important beneath regions of recent ice mass loss and recently observed remarkably high rates of GIA-induced bedrock uplift, such as the Amundsen Sea Embayment.