This study aims to determine the influence of talent management and knowledge management on the performance of employees of PT. Perkebunan Nusantara II Tanjung Morawa. The population in this study as many as 522 employees, and a sample of 84 people using stratification sample technique. Data collection technique used is through questionnaire (measurement) with the likert scale and processed statistically using multiple regression analysis and testing of t test hypothesis, f test, and determinant coefficient.From the data analysis of each variable obtained by multiple regression equation Y = 5,612 + 0,469 X1 + 0,598 X2 + e. Obtained R2 of 0.756, which means X1 and X2 explain the effect on the variable Y of 75.6% while the rest described other variables outside the study. The partial test of each independent variable has an effect on the dependent variable with the research significance is smaller than 0.1 so the hypothesis is accepted, and the result of simultaneous test calculation is 125.217 with ftable 2.37 which means Fcount> Ftable with level of significant (α) 0.000 Ftabel dengan level of significant (α) 0,000 < 0,1, yang artinya hipotesis diterima yaitu talent management dan knowledge management secara bersama-sama berpengaruh signifikan terhadap kinerja karyawan PT. Perkebunan Nusantara II Tanjung Morawa.