Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls
Open Access
- 8 June 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 10 (1), 1-13
- https://doi.org/10.1038/s41398-020-00871-w
Abstract
Advances in the treatment of bulimia nervosa and binge-eating disorder (BN/BED) have been marred by our limited understanding of the underpinning neurobiology. Here we measured regional cerebral blood flow (rCBF) to map resting perfusion abnormalities in women with BN/BED compared with healthy controls and investigate whether intranasal oxytocin (OT), proposed as a potential treatment, can restore perfusion in disorder-related brain circuits. Twenty-four women with BN/BED and 23 healthy women participated in a randomized, double-blind, crossover, placebo-controlled study. We used arterial spin labelling MRI to measure rCBF and the effects of an acute dose of intranasal OT (40 IU) or placebo over 18–26 min post dosing, as we have previously shown robust OT-induced changes in resting rCBF in men in a similar time-window (15–36 min post dosing). We tested for effects of treatment, diagnosis and their interaction on extracted rCBF values in anatomical regions-of-interest previously implicated in BN/BED by other neuroimaging modalities, and conducted exploratory whole-brain analyses to investigate previously unidentified brain regions. We demonstrated that women with BN/BED presented increased resting rCBF in the medial prefrontal and orbitofrontal cortices, anterior cingulate gyrus, posterior insula and middle/inferior temporal gyri bilaterally. Hyperperfusion in these areas specifically correlated with eating symptoms severity in patients. Our data did not support a normalizing effect of intranasal OT on perfusion abnormalities in these patients, at least for the specific dose (40 IU) and post-dosing interval (18–26 min) examined. Our findings enhance our understanding of resting brain abnormalities in BN/BED and identify resting rCBF as a non-invasive potential biomarker for disease-related changes and treatment monitoring. They also highlight the need for a comprehensive investigation of intranasal OT pharmacodynamics in women before we can fully ascertain its therapeutic value in disorders affecting predominantly this gender, such as BN/BED.Funding Information
- RCUK | Economic and Social Research Council (ES/K009400/1)
- King's Health Partners
This publication has 105 references indexed in Scilit:
- An fMRI Study of Self-Regulatory Control and Conflict Resolution in Adolescents With Bulimia NervosaAmerican Journal of Psychiatry, 2011
- Cerebral Blood Flow during Rest Associates with General Intelligence and CreativityPLOS ONE, 2011
- P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor GatingPLOS ONE, 2011
- Potentials and Challenges for Arterial Spin Labeling in Pharmacological Magnetic Resonance ImagingThe Journal of pharmacology and experimental therapeutics, 2011
- Neuroscience of Self and Self-RegulationAnnual Review of Psychology, 2011
- Cerebral Blood Flow Response to Functional ActivationJournal of Cerebral Blood Flow & Metabolism, 2009
- ‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disordersPhysiology & Behavior, 2009
- Rasch model analysis of the Depression, Anxiety and Stress Scales (DASS)BMC Psychiatry, 2009
- Deficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia NervosaArchives of General Psychiatry, 2009
- Clinical Neuroimaging Using Arterial Spin-Labeled Perfusion Magnetic Resonance ImagingNeurotherapeutics, 2007