A Polymorphism in the Catalase Gene Promoter Confers Protection against Severe RSV Bronchiolitis
Open Access
- 3 January 2020
- Vol. 12 (1), 57
- https://doi.org/10.3390/v12010057
Abstract
Respiratory syncytial virus (RSV) infection is associated with oxidative lung injury, decreased levels of antioxidant enzymes (AOEs), and the degradation of the transcription factor NF-E2-related factor 2 (NRF2), a master regulator of AOE expression. Single nucleotide polymorphisms (SNPs) in AOE and NRF2 genes have been associated with various lung disorders. To test whether specific NRF2 and/or AOE gene SNPs in children with RSV lower respiratory tract infection were associated with disease severity, one hundred and forty one children p = 0.01, OR 0.38) among patients with moderate to severe RSV bronchiolitis, suggesting a protective effect against disease severity. Our results suggest that increasing catalase expression/activity could exert a protective role in the context of RSV infection and represent a potential novel therapeutic target to ameliorate viral-induced lung disease.Keywords
Funding Information
- National Institutes of Health (AI25434, AI062885, ES026782, TL1TR001440)
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