The Gut-Brain-Axis on the Manifestation of Depressive Symptoms in Epilepsy: An Evidence-Driven Hypothesis
Open Access
- 8 April 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 11, 465
- https://doi.org/10.3389/fphar.2020.00465
Abstract
Epilepsy is a severe neurological disorder involving 70 million people around the globe. Epilepsy-related neuropsychiatric comorbidities such as depression, which is the most common, is an additional factor that negatively impacts the living quality of epilepsy patients. There are many theories and complexities associated with both epilepsy and associated comorbidities, one of which is the gut-brain-axis influence. The gut microbiome is hypothesized to be linked with many neurological disorders; however, little conclusive evidence is available in this area. Thus, highlighting the role will create interest in researchers to conduct detailed research in comprehending the influence of gut-brain-axis in the manifestation of depressive symptoms in epilepsy. The hypothesis which is explored in this review is that the gut-brain-axis do play an important role in the genesis of epilepsy and associated depression. The correction of this dysbiosis might be beneficial in treating both epilepsy and related depression. This hypothesis is illustrated through extensive literature discussion, proposed experimental models, and its applicability in the field. There is indirect evidence which revealed some specific bacterial strains that might cause depression in epilepsy.This publication has 105 references indexed in Scilit:
- The Effect of High-Fat Diet-Induced Pathophysiological Changes in the Gut on Obesity: What Should be the Ideal Treatment?Clinical and Translational Gastroenterology, 2013
- Vagal Nerve Stimulation Rapidly Activates Brain-Derived Neurotrophic Factor Receptor TrkB in Rat BrainPLOS ONE, 2012
- Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerveProceedings of the National Academy of Sciences of the United States of America, 2011
- A Systematic Review of the Frequency of Neurocyticercosis with a Focus on People with EpilepsyPLoS Neglected Tropical Diseases, 2010
- Depressive symptoms in patients with epilepsy: Analysis of self-rating and physician′s assessmentNeurology India, 2010
- Intestinal membrane permeability and hypersensitivity in the irritable bowel syndromePain, 2009
- The descriptive epidemiology of epilepsy—A reviewEpilepsy Research, 2009
- The Effects of Chronic Norepinephrine Transporter Inactivation on Seizure Susceptibility in MiceNeuropsychopharmacology, 2005
- The epidemiology of epilepsy revisitedCurrent Opinion in Neurology, 2003
- Epilepsy in elderly peopleThe Lancet, 2000