Mitochondrial carrier homolog 2 is necessary for AML survival
- 2 July 2020
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 136 (1), 81-92
- https://doi.org/10.1182/blood.2019000106
Abstract
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial carrier homolog 2 (MTCH2). In AML, knockdown of MTCH2 decreased growth, reduced engraftment potential of stem cells, and induced differentiation. Inhibiting MTCH2 in AML cells in- creased nuclear pyruvate and pyruvate dehydrogenase (PDH), which induced histone acetylation and subsequently promoted the differentiation of AML cells. Thus, we have defined a new mechanism by which mitochondria and metabolism regulate AML stem cells and gene expression.This publication has 30 references indexed in Scilit:
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