A Survey of 61 Veterinary Drug Residues in Commercial Liquid Milk Products in China

Abstract

To investigate the drug residue situation in commercial liquid milk products in China, 190 samples, including ultra-high temperature (UHT) milk (n=168) and pasteurized (n=22) milk samples, were collected in 2019. Milk samples were analyzed for the presence of any of the sixty-one veterinary drugs in them by using a screening assay combined with a UPLC-MS/MS analysis. Ten (5.26%) samples were found positive for β-lactams, tetracyclines, aminoglycosides, and 6 (3.16%) samples were confirmed residual for penicillin G (n=6, 3.16%), tetracycline (n=1, 0.53%) and oxytetracycline (n=1, 0.53%) with the maximum concentration of 2.85 μg kg-1, 40.64 μg kg-1, and 12.35 μg kg-1, respectively. Drug residue detection rate in Group II (4.55%, the local city domestic brands) was higher than that in Group I (2.70%, the major brands of China) and Group III (2.78%, the imported brands into China), and higher in domestic samples (3.39%) than that in imported samples (2.78%), and higher in pasteurized milk samples (9.09%) than that in UHT milk samples (2.38%). All drug residue levels were far below the regulated maximum residue limits. However, based on some veterinary drug residues detected in the sampling samples, there is a potential veterinary drug risk in liquid milk products in the Chinese market, which deserves the attention of governments and consumers.