Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection
Open Access
- 5 July 2021
- Vol. 9 (7), 742
- https://doi.org/10.3390/vaccines9070742
Abstract
The main expected result of a vaccine against viruses is the ability to produce neutralizing antibodies. Currently, several vaccines against SARS-CoV-2 are being applied to prevent mortal complications, being Pfizer-BioNTech (BNT162b2) one of the first to be authorized in the USA and Mexico (11 December 2020). This study evaluated the efficacy of this vaccine on antibody production with neutralizing capacity and its side effects in healthcare workers with and without prior SARS-CoV-2 infection and in a group of unvaccinated individuals with prior COVID-19. The main findings are the production of 100% neutralizing antibodies in both groups after the second dose, well-tolerated adverse effects, the possible presence of immunosenescence, and finally, we support that a single dose of this vaccine in individuals with prior COVID-19 would be sufficient to achieve an immunization comparable to people without prior COVID-19 with a complete vaccination program (2 doses).This publication has 37 references indexed in Scilit:
- Manifestaciones cutáneas asociadas a la enfermedad por el nuevo coronavirus SARS-CoV-2Medicina Clinica, 2020
- COVID-19 Serological Tests: How Well Do They Actually Perform?Diagnostics, 2020
- Comorbidity and its Impact on Patients with COVID-19SN Comprehensive Clinical Medicine, 2020
- A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2Allergy, 2020
- COVID-19, quarantine, and atopic dermatitisMedical Hypotheses, 2020
- COVID-19: Progress in diagnostics, therapy and vaccinationTheranostics, 2020
- Glucocorticoids, Sex Hormones, and ImmunityFrontiers in Immunology, 2018
- B-cell biology and developmentJournal of Allergy and Clinical Immunology, 2013
- Immunosenescence and Novel Vaccination Strategies for the ElderlyFrontiers in Immunology, 2013
- Immunosenescence and vaccine failure in the elderlyAging Clinical and Experimental Research, 2009