Synthesis of nitrogen heterocycles from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate
Open Access
- 30 September 2011
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 2 (3), 295-299
- https://doi.org/10.5155/eurjchem.2.3.295-299.376
Abstract
An efficient synthesis of nitrogen-containing heterocycles pyrazole, triazole, pyridinone and pyrimidinone derivatives from ethyl 3-(6-dibenzothiophen-2-yl-pyridazin-3-ylamino)-3-oxopropanoate (2) was described. The structures of all products were confirmed and characterized by the elemental analysis and spectroscopic studies (IR, MS, 1H NMR, 13C NMR).Keywords
This publication has 20 references indexed in Scilit:
- Discovery of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationshipBioorganic & Medicinal Chemistry Letters, 2010
- Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory painBioorganic & Medicinal Chemistry Letters, 2010
- Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)Bioorganic & Medicinal Chemistry Letters, 2010
- Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitorsBioorganic & Medicinal Chemistry Letters, 2009
- Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)Bioorganic & Medicinal Chemistry Letters, 2009
- Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinaseBioorganic & Medicinal Chemistry Letters, 2009
- New pyridazine derivatives: Synthesis, chemistry and biological activityBioorganic & Medicinal Chemistry, 2009
- Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitorsBioorganic & Medicinal Chemistry Letters, 2008
- Selenium containing heterocycles: Synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivativesEuropean Journal of Medicinal Chemistry, 2008
- Synthesis and cytotoxic activity of N,N-bis-{3-[N-(4-chlorobenzo[g]-phthalazin-1-yl)]aminopropyl}-N-methylamine: a new potential DNA bisintercalatorBioorganic & Medicinal Chemistry, 2003