Meta-analysis of diagnostic and prognostic value of miR-126 in non-small cell lung cancer

Abstract

In recent years, many studies on the relationship between the expression of microRNA-126(miR-126) and the diagnostic and prognostic value of non-small cell lung cancer (NSCLC)have been made, but the results were still controversial.The aim is to explore the expression of miR-126 and the diagnosis and prognosis value of NSCLC, and to provide relevant evidence for clinical diagnosis and treatment. literature related to miR-126 and NSCLC were searched in PubMed, Embase, Cochrane Library, Web of Science, CNKI and Wanfang from the inception to February 2020. Stata 15.0 was used for meta-analysis. The diagnostic value data were used to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and the prognostic value data were used to calculate the pooled risk ratio (HR) of overall survival (OS) and its 95% confidence interval(95%CI).Thirteen studies were included, among which 5 were related to diagnosis containing 439 patients and 463 healthy controls，and 8 related to prognosis containing 1102 patients. The results of miR-126 expression and diagnostic value of NSCLC showed that the pooled sensitivity was 0.83 (95%CI: 0.59~0.94), specificity=0.83(95%CI: 0.71~0.90), PLR=4.78(95%CI: 2.97~7.69), NLR=0.20(95%CI: 0.08~0.54), DOR=23.48(95%CI: 7.87~70.10), and the area under the SROC curve was 0.89 (95%CI:0.86~0.91). The results of prognostic value indicated that The expression of miR-126 was related to the OS of NSCLC (HR=0.79 ,95%CI:0.63~0.98). In conclusion, The expression of miR-126 has medium diagnostic value, and it’s related to the prognosis of patients with NSCLC,with poor prognosis of miR-126 low expression.