Stability and Predictors of Poor 6-min Walking Test Performance over 2 Years in Patients with COPD
Open Access
- 18 April 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (4), 1155
- https://doi.org/10.3390/jcm9041155
Abstract
Poor performance in the 6-min walk test (6MWT < 350 m) is an important prognostic indicator of mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Little is known about the stability of this state over time and what factors might predict a poor 6MWT performance. To determine the stability of 6MWT performance over a 2-year period in COPD patients participating in annual medical follow-up visits, and to assess the ability of several clinical, pulmonary, and non-pulmonary factors to predict poor 6MWT performance, we prospectively included 137 patients with stable COPD (mean age, 66.9 ± 8.3 years). The 6MWT was scored at baseline and 2-year follow-up. To evaluate clinical, pulmonary, and non-pulmonary variables as potential predictors of poor 6MWT performance, we used multiple logistic regression models adjusted for age, sex, weight, height, and 6MWT performance at baseline. Poor 6MWT performance was stable over 2 years for 67.4% of patients. Predictors of poor 6MWT performance included a five-repetition sit-to-stand test score ≤2 (OR, 3.01; 95% CI, 1.22–7.42), the percentage of mobility activities with limitations (OR, 1.03; 95% CI, 1.00–1.07), and poor 6MWT performance at baseline (OR, 4.64; 95% CI, 1.88–11.43). Poor 6MWT performance status was stable for the majority of COPD patients. Lower scores on the five-repetition sit-to-stand test and a higher number of mobility activities with limitations were relevant predictors of poor 6MWT performance over 2 years. Prognostic models based on these non-pulmonary factors can provide non-inferior discriminative ability in comparison with prognostic models based on only pulmonary factors.Keywords
This publication has 29 references indexed in Scilit:
- The COPD control panel: towards personalised medicine in COPDThorax, 2012
- Predicting Outcomes from 6-Minute Walk Distance in Chronic Obstructive Pulmonary DiseaseJournal of the American Medical Directors Association, 2012
- Daily Physical Activity in Patients with Chronic Obstructive Pulmonary Disease: A Systematic ReviewCOPD: Journal of Chronic Obstructive Pulmonary Disease, 2011
- Validation and comparison of reference equations for the 6-min walk distance testEuropean Respiratory Journal, 2008
- The 6-min walking distance: long-term follow up in patients with COPDEuropean Respiratory Journal, 2007
- Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paperEuropean Respiratory Journal, 2004
- The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary DiseaseThe New England Journal of Medicine, 2004
- The 6-min walk distance: change over time and value as a predictor of survival in severe COPDEuropean Respiratory Journal, 2004
- The 6-min Walk Test*Social psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2003
- ATS StatementAmerican Journal of Respiratory and Critical Care Medicine, 2002