Vaccine-Induced Thrombocytopenia with Severe Headache
- 25 November 2021
- journal article
- letter
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 385 (22), 2103-2105
- https://doi.org/10.1056/nejmc2112974
Abstract
Vaccine-induced immune thrombotic thrombocytopenia (VITT), a serious adverse event after vaccination with ChAdOx1 nCoV-19 (AstraZeneca) or Ad26.COV2.S (Johnson & Johnson–Janssen), is caused by platelet factor 4 (PF4)–dependent, platelet-activating antibodies.1-3 High-dose immune globulins and anticoagulation are the main treatments.4,5 In this report, we present evidence that vaccine-induced thrombocytopenia (VIT) without associated cerebral venous sinus thrombosis (CVST) or other thromboses and with severe headache as the heraldic symptom may precede VITT (“pre-VITT syndrome”).Funding Information
- Deutsche Forschungsgemeinschaft (374031971 – TRR 240)
- Universitätsmedizin Greifswald (Domagk-Programm of the Universitätsmedizin Greifs)
This publication has 5 references indexed in Scilit:
- Thrombosis with thrombocytopenia syndrome associated with COVID-19 vaccinesThe American Journal of Emergency Medicine, 2021
- Adjunct Immune Globulin for Vaccine-Induced Immune Thrombotic ThrombocytopeniaThe New England Journal of Medicine, 2021
- Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 VaccinationThe New England Journal of Medicine, 2021
- Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 VaccinationThe New England Journal of Medicine, 2021