Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents
Open Access
- 1 January 2013
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Open Journal of Medicinal Chemistry
- Vol. 03 (04), 128-135
- https://doi.org/10.4236/ojmc.2013.34015
Abstract
A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious antitubercular activities could be observed (MIC > 10 ug/mL). The results are in sharp contrast with the previously reported data.Keywords
This publication has 10 references indexed in Scilit:
- Global tuberculosis control: lessons learnt and future prospectsNature Reviews Microbiology, 2012
- Enantioselective synthesis of 2-amino-4H-pyrans via the organocatalytic cascade reaction of malononitrile and α-substituted chalconesTetrahedron: Asymmetry, 2012
- Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine EfficacyPLOS ONE, 2012
- Fighting resistant tuberculosis with old compounds: the carbapenem paradigmClinical Microbiology & Infection, 2011
- Antimycobacterial activity of novel 1,2,4-oxadiazole-pyranopyridine/chromene hybrids generated by chemoselective 1,3-dipolar cycloadditions of nitrile oxidesBioorganic & Medicinal Chemistry, 2011
- Multidrug-resistant Mycobacterium tuberculosis: A Brief ReviewAsian Journal of Biological Sciences, 2011
- Highly enantioselective synthesis of α-trichloromethyldihydropyrans catalyzed by bifunctional organocatalystsTetrahedron, 2011
- Drug-resistant and extensively drug-resistant tuberculosis in southern AfricaCurrent Opinion in Pulmonary Medicine, 2010
- Development of New Anti-tuberculosis Drug CandidatesThe Tohoku Journal of Experimental Medicine, 2010
- An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitrilesBioorganic & Medicinal Chemistry Letters, 2007