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Tight Junction Protein (Claudin-4) and Inflammatory Regulator (COX-2) Expression in Nasopharyngeal Carcinoma: An Immunohistochemical Study

The Medical Journal of Cairo University , Volume 87, pp 4387-4395; doi:10.21608/mjcu.2019.78256

Abstract: Background: Claudin 4 is one of the tight junction proteins which considered one of the protective barriers that are mostly involved in the regulation of intercellular communication, paracellular transport and apical cell-to-cell adhesion. Over-expression of COX-2 and subsequent increase in prostaglandins (PGs) concentration have emerged in recent years as important players in cancer progression.Aim of Study: To explore immunohisto chemically the expression of both claudin-4 and COX2 in nasopharyngeal carcinoma and correlate their expression with each other and with different clinicopathological parameters.Material and Methods: This retrospective study was done upon formalin fixed, paraffin blocks of 32 nasopharngeal carcinoma cases and 6 non-neoplastic nasopharyngeal epithe-lium. The materials were obtained from archieves of Pathology Departement and Early Cancer Detection Unit (ECDU), Faculty of Medicine, Benha University during the years 2012- 2017. The immunohistochemical stain with Claudin 4 and COX2 was done and evaluated for each case.Results: High expression of claudin 4 was observed in 44% of studied nasopharyngeal cases with statistically signif-icant correlation with tumor stage and distant metastasis (p
Keywords: Treatment / survival / proteins / Adhesion / claudin / distant metastasis / Immunohistochemical / neoplastic

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