Recent advances in targeting cancer stem cells using oncolytic viruses
- 12 March 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Biotechnology Letters
- Vol. 42 (6), 865-874
- https://doi.org/10.1007/s10529-020-02857-6
Abstract
Oncolytic virotherapy is a promising antitumor strategy which utilizes the lytic nature of viral replication to kill cancer cells. Oncolytic viruses (OVs) can induce cancer cell death and trigger immune responses to metastatic cancer in vivo. Reverse genetic systems have aided the insertion of anticancer genes into various OVs to augment their oncolytic capacity. Furthermore, OVs target and destroy the population of tumor-initiating cancer stem cells. These cancer stem cells are associated with metastasis and development of resistance to conventional anticancer approaches. Targeting cancer stem cells is essential since killing only differentiated tumor cells may lead to enrichment of cancer stem cells and thus indicate a poor prognosis. In this review, we summarize the oncolytic activity of various classes of OVs towards different types of cancer stem cells and also discuss the synergistic activity achieved by the combination of OVs with traditional therapies on chemo- and radiotherapy-resistant cancer stem cells.Keywords
Funding Information
- National Natural Science Foundation of China (81672430, 81602706)
- Zhejiang Provincial Medical and Healthy Science and Technology Projects (2019KY248)
This publication has 56 references indexed in Scilit:
- Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade ImmunotherapyScience Translational Medicine, 2014
- Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivoOncology Reports, 2013
- Cancer stem cellsThe International Journal of Biochemistry & Cell Biology, 2012
- Clonal evolution in cancerNature, 2012
- The cancer stem cell paradigm: a new understanding of tumor development and treatmentEmerging Therapeutic Targets, 2010
- Intelligent Design: Combination Therapy With Oncolytic VirusesMolecular Therapy, 2010
- Association of reactive oxygen species levels and radioresistance in cancer stem cellsNature, 2009
- Cancer stem cell markers in common cancers – therapeutic implicationsTrends in Molecular Medicine, 2008
- Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem CellsCancer Research, 2006
- Target for cancer therapy: proliferating cells or stem cellsLeukemia, 2005