Magnetic Resonance Imaging and Clinical Features of the Demyelinating Degeneration of White Matter in Young Patients
Open Access
- 1 July 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in International Journal of General Medicine
- Vol. ume 14, 3177-3186
- https://doi.org/10.2147/ijgm.s302587
Abstract
Objective: Magnetic resonance imaging (MRI) of brain white matter demyelination often focuses on demyelinating disease, cerebral small vascular disease diagnosis, and follow-up of cognitive dysfunction for observation. This study explored MRI findings and clinical manifestations of demyelinating degeneration of white matter in young patients. Methods: A total of ninety-four patients with white matter degeneration diagnosed with MRI were enrolled in this study from January 2014 to July 2018. These patients were divided into two groups: the demyelinating disease group (n = 43) and the non-demyelinating disease group (n = 51). The imaging findings and clinical manifestations of the two groups were analyzed. Results: Compared with the non-demyelinating group, there were more female than male patients in the demyelinating group (P < 0.05). In addition, of the 45 patients with an imaging result of “demyelinating degeneration of white matter and multiple sclerosis,” 39 patients met the diagnosis of multiple sclerosis (86.7%). In comparison, of the 49 patients with an imaging result of “demyelinating degeneration of white matter,” only four patients met the diagnosis for demyelinating disease (8.2%). Conclusion: In patients complaining of headaches, dizziness, vertigo, and other symptoms and in the case of an imaging result showing the demyelinating degeneration of white matter alone, the possibility of a clinical diagnosis of a demyelinating disease is minimal.Keywords
This publication has 27 references indexed in Scilit:
- MRI in multiple sclerosis: what is changing?Current Opinion in Neurology, 2018
- Effective Utilization of MRI in the Diagnosis and Management of Multiple SclerosisNeurologic Clinics, 2018
- Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous systemPublished by Elsevier BV ,2018
- Inflammatory demyelinating diseases of the central nervous systemPublished by Elsevier BV ,2017
- Health-care use before a first demyelinating event suggestive of a multiple sclerosis prodrome: a matched cohort studyThe Lancet Neurology, 2017
- Cause and prevention of demyelination in a model multiple sclerosis lesionAnnals of Neurology, 2016
- Association of Leukoaraiosis With Convalescent Rehabilitation Outcome in Patients With Ischemic StrokeStroke, 2016
- Decreased Number of Mitochondria in LeukoaraiosisArchives of Medical Research, 2015
- Axonal Transection in the Lesions of Multiple SclerosisThe New England Journal of Medicine, 1998
- MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal agingAmerican Journal of Roentgenology, 1987