Oseltamivir treatment of influenza A and B infections in infants
Open Access
- 3 May 2021
- journal article
- research article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 15 (5), 618-624
- https://doi.org/10.1111/irv.12862
Abstract
Background Oseltamivir treatment is currently the only way of managing influenza in young infants for whom influenza vaccines are not licensed, but little data exist on the effectiveness of the treatment in this age group. Methods In a prospective study, we enrolled 431 newborn infants and followed them up for 10 months during their first respiratory season (September 2017‐June 2018). During each respiratory illness, we examined the infants and obtained nasopharyngeal specimens for determination of the viral etiology. Infants with influenza were re‐examined at short intervals, and additional nasopharyngeal specimens were obtained at each visit for measuring the viral load. All infants with symptoms P = .0003). For infants with influenza B, the corresponding durations were 110.0 and 173.9 hours, respectively (P = .03). In infants with influenza A, total symptom scores were significantly lower in oseltamivir‐treated infants at all time points between days 3 and 11 after the onset of therapy. In most children with either influenza A or B, viral antigen concentrations declined rapidly within 1‐2 days after the initiation of oseltamivir treatment. Conclusions Oseltamivir treatment of infants with influenza rapidly decreased the viral load in nasopharyngeal secretions and shortened the duration and severity of symptoms. The clinical effectiveness of oseltamivir appeared to be greater against influenza A than against influenza B infections.Keywords
Funding Information
- Instrumentariumin Tiedesäätiö
- Lastentautien Tutkimussäätiö
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Hengityssairauksien Tutkimussäätiö
- Business Finland (534/14)
This publication has 26 references indexed in Scilit:
- Vaccination of Healthy Children Against Seasonal InfluenzaThe Pediatric Infectious Disease Journal, 2013
- Admission diagnoses of children 0–16 years of age hospitalized with influenzaEuropean Journal of Clinical Microbiology & Infectious Diseases, 2011
- Incidence of Influenza-related Hospitalizations in Different Age Groups of Children in FinlandThe Pediatric Infectious Disease Journal, 2011
- Early Oseltamivir Treatment of Influenza in Children 1–3 Years of Age: A Randomized Controlled TrialClinical Infectious Diseases, 2010
- Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: Do children of all ages respond equally?Vaccine, 2010
- Oseltamivir for Treatment of Influenza in Infants Less Than One YearThe Pediatric Infectious Disease Journal, 2010
- Lower Clinical Effectiveness of Oseltamivir against Influenza B Contrasted with Influenza A Infection in ChildrenClinical Infectious Diseases, 2007
- A Comparison of the Effectiveness of Oseltamivir for the Treatment of Influenza A and Influenza B: A Japanese Multicenter Study of the 2003-2004 and 2004-2005 Influenza SeasonsClinical Infectious Diseases, 2006
- The Underrecognized Burden of Influenza in Young ChildrenThe New England Journal of Medicine, 2006
- Accuracy of Clinical Diagnosis of Influenza in Outpatient ChildrenClinical Infectious Diseases, 2005