The roadmap towards elimination of lymphatic filariasis by 2030: insights from quantitative and mathematical modelling
Open Access
- 13 September 2019
- journal article
- Published by F1000 Research Ltd in Gates Open Research
- Vol. 3, 1538
- https://doi.org/10.12688/gatesopenres.13065.1
Abstract
The Global Programme to Eliminate Lymphatic Filariasis was launched in 2000 to eliminate lymphatic filariasis (LF) as a public health problem by 1) interrupting transmission through mass drug administration (MDA) and 2) offering basic care to those suffering from lymphoedema or hydrocele due to the infection. Although impressive progress has been made, the initial target year of 2020 will not be met everywhere. The World Health Organization recently proposed 2030 as the new target year for elimination of lymphatic filariasis (LF) as a public health problem. In this letter, LF modelers of the Neglected Tropical Diseases (NTDs) Modelling Consortium reflect on the proposed targets for 2030 from a quantitative perspective. While elimination as a public health problem seems technically and operationally feasible, it is uncertain whether this will eventually also lead to complete elimination of transmission. The risk of resurgence needs to be mitigated by strong surveillance after stopping interventions and sometimes perhaps additional interventions.Funding Information
- Gates Foundation (OPP1186851, OPP1156227, OPP1184344)
This publication has 45 references indexed in Scilit:
- Modelling Lymphatic Filariasis Transmission and Control: Modelling Frameworks, Lessons Learned and Future DirectionsAdvances In Parasitology, Vol 64, 2015
- Surveillance and response: Tools and approaches for the elimination stage of neglected tropical diseasesActa Tropica, 2015
- A Comprehensive Assessment of Lymphatic Filariasis in Sri Lanka Six Years after Cessation of Mass Drug AdministrationPLoS Neglected Tropical Diseases, 2014
- Modeling the Impact and Costs of Semiannual Mass Drug Administration for Accelerated Elimination of Lymphatic FilariasisPLoS Neglected Tropical Diseases, 2013
- Improving community participation to eliminate lymphatic filariasis in American SamoaActa Tropica, 2011
- High coverage of mass drug administration for lymphatic filariasis in rural and non-rural settings in the Western Area, Sierra LeoneParasites & Vectors, 2010
- Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasisBMC Biology, 2010
- LYMFASIM, a simulation model for predicting the impact of lymphatic filariasis control: quantification for African villagesParasitology, 2008
- Social mobilisation, drug coverage and compliance and adverse reactions in a Mass Drug Administration (MDA) Programme for the Elimination of Lymphatic Filariasis in Sri LankaFilaria Journal, 2007
- Determinants of the eradicability of filarial infections: a conceptual approachTrends in Parasitology, 2005