Surface texture limits transfer of S. aureus, T4 bacteriophage, influenza B virus and human coronavirus
Open Access
- 28 December 2020
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 15 (12), e0244518
- https://doi.org/10.1371/journal.pone.0244518
Abstract
Spread of pathogens on contaminated surfaces plays a key role in disease transmission. Surface technologies that control pathogen transfer can help control fomite transmission and are of great interest to public health. Here, we report a novel bead transfer method for evaluating fomite transmission in common laboratory settings. We show that this method meets several important criteria for quantitative test methods, including reasonableness, relevancy, resemblance, responsiveness, and repeatability, and therefore may be adaptable for standardization. In addition, this method can be applied to a wide variety of pathogens including bacteria, phage, and human viruses. Using the bead transfer method, we demonstrate that an engineered micropattern limits transfer of Staphylococcus aureus by 97.8% and T4 bacteriophage by 93.0% on silicone surfaces. Furthermore, the micropattern significantly reduces transfer of influenza B virus and human coronavirus on silicone and polypropylene surfaces. Our results highlight the potential of using surface texture as a valuable new strategy in combating infectious diseases.Funding Information
- Sharklet Internal Funding
This publication has 40 references indexed in Scilit:
- Surface micropattern limits bacterial contaminationPublished by Springer Science and Business Media LLC ,2014
- Micro‐patterned surfaces reduce bacterial colonization and biofilm formation in vitro: Potential for enhancing endotracheal tube designsClinical and Translational Medicine, 2014
- Transfer Efficiency of Bacteria and Viruses from Porous and Nonporous Fomites to Fingers under Different Relative Humidity ConditionsApplied and Environmental Microbiology, 2013
- Air-directed attachment of coccoid bacteria to the surface of superhydrophobic lotus-like titaniumBiofouling, 2012
- Survival and transmission of community-associated methicillin-resistant Staphylococcus aureus from fomitesAmerican Journal of Infection Control, 2011
- Virus transfer between fingerpads and fomitesJournal of Applied Microbiology, 2010
- Engineered Nanoforce Gradients for Inhibition of Settlement (Attachment) of Swimming Algal SporesLangmuir, 2008
- Significance of Fomites in the Spread of Respiratory and Enteric Viral DiseaseApplied and Environmental Microbiology, 2007
- The effect of polymer surface on the wetting and adhesion of liquid systemsJournal of Adhesion Science and Technology, 2007
- Engineered antifouling microtopographies – correlating wettability with cell attachmentBiofouling, 2006