Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease
Open Access
- 20 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 21 (1), 1-9
- https://doi.org/10.1186/s12931-020-01345-9
Abstract
Local airway inflammation may cause systemic changes which result in endothelial dysfunction. Only a few studies have used reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with chronic obstructive pulmonary disease (COPD) in order to measure their endothelial dysfunction. To determine the efficacy of endothelial dysfunction, measured by RH-PAT, in assessing disease severity and systemic burden in a cohort of COPD patients. In this prospective, monocentric study, 157 patients with moderate to very severe COPD (GOLD class II-IV) were examined for endothelial dysfunction using RH-PAT (Itamar medical Ltd., Caesarea, Israel). In a nested-cohort, examination was repeated at exacerbation. The association between reactive hyperemia index (RHI), augmentation index (AI) and disease severity and outcome parameters was analysed. 57% of the COPD patients had a dysfunctional endothelium and the median (IQR) RHI was 1.42 (1.27–1.53). Exacerbation of COPD was not associated with a significant change in RHI (p = 0.625) or ΑΙ (p = 0.530). None of the diagnostic or clinical outcomes of COPD was associated with RHI or arterial stiffness. Endothelial dysfunction is common in COPD. However, it does not seem to be a predictor neither of disease severity, nor of outcome and does not change during exacerbations of the disease.Funding Information
- Swiss Re Foundation (PP00-P3_128412/1)
This publication has 48 references indexed in Scilit:
- Peripheral Endothelial Function and Cardiovascular Events in High‐Risk PatientsJournal of the American Heart Association, 2013
- Reproducibility of peripheral arterial tonometry for the assessment of endothelial function in adultsJournal of Hypertension, 2013
- The association between COPD and heart failure risk: a reviewInternational Journal of Chronic Obstructive Pulmonary Disease, 2013
- Relationship between coronary endothelial function and coronary calcification in early atherosclerosisAtherosclerosis, 2010
- Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse eventsEuropean Heart Journal, 2010
- Development and first validation of the COPD Assessment TestEuropean Respiratory Journal, 2009
- Cross-Sectional Relations of Digital Vascular Function to Cardiovascular Risk Factors in the Framingham Heart StudyCirculation, 2008
- Impaired Flow-mediated Dilation Is Associated with Low Pulmonary Function and Emphysema in Ex-smokersAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Projections of Global Mortality and Burden of Disease from 2002 to 2030PLoS Medicine, 2006
- Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitudeAmerican Heart Journal, 2003