Eph receptors: the bridge linking host and virus
Open Access
- 31 December 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 77 (12), 2355-2365
- https://doi.org/10.1007/s00018-019-03409-6
Abstract
Eph (erythropoietin-producing hepatoma) receptors and Ephrin ligands constitute the largest subfamily of receptor tyrosine kinase (RTK), which were first discovered in tumors. Heretofore, Eph protein has been shown to be involved in various tumor biological behaviors including proliferation and progression. The occurrence of specific types of tumor is closely related to the virus infection. Virus entry is a complex process characterized by a series of events. The entry into target cells is an essential step for virus to cause diseases, which requires the fusion of the viral envelope and host cellular membrane mediated by viral glycoproteins and cellular receptors. Integrin molecules are well known as entry receptors for most herpes viruses. However, in recent years, Eph receptors and their Ephrin ligands have been reported to be involved in virus infections. The main mechanism may be the interaction between Eph receptors and conserved viral surface glycoprotein, such as the gH/gL or gB protein of the herpesviridae. This review focuses on the relationship between Eph receptor family and virus infection that summarize the processes of viruses such as EBV, KSHV, HCV, RRV, etc., infecting target cells through Eph receptors and activating its downstream signaling pathways resulting in malignancies. Finally, we discussed the perspectives to block virus infection, prevention, and treatment of viral-related tumors via Eph receptor family.Keywords
Funding Information
- National Natural Science Foundation of China (81702919, 81802478)
- Guangxi Natural Science Foundation (2017JJB10161, 2018JJB140315)
This publication has 115 references indexed in Scilit:
- Ephrin-B2 and ephrin-B3 as functional henipavirus receptorsSeminars in Cell & Developmental Biology, 2012
- EphA receptor signaling—Complexity and emerging themesSeminars in Cell & Developmental Biology, 2012
- Non-SH2/PDZ reverse signaling by ephrinsSeminars in Cell & Developmental Biology, 2012
- Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cellsCellular Signalling, 2011
- Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related OncogenesisPublished by Elsevier BV ,2010
- Genome-wide RNAi screen identifies human host factors crucial for influenza virus replicationNature, 2010
- EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with AktCancer Cell, 2009
- Eph-Ephrin Bidirectional Signaling in Physiology and DiseaseCell, 2008
- Cell–cell signaling via Eph receptors and ephrinsCurrent Opinion in Cell Biology, 2007
- Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancerNature Genetics, 2004