Assessment of risk compensation following use of the dapivirine vaginal ring in southwestern Uganda
Open Access
- 4 February 2021
- journal article
- research article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 98 (1), 32-37
- https://doi.org/10.1136/sextrans-2020-054718
Abstract
Objectives: Participation in HIV prevention trials could trigger risk compensation among participants. We evaluated potential risk compensation following use of a vaginal ring microbicide by women in a phase III trial in southwestern Uganda.Methods: We used markers of sexual risk behaviour documented on standardised questionnaires, tested for STIs at baseline and quarterly for 2 years. Risk compensation was defined as a significant increase (trend pTrichomonas vaginalis pNeisseria gonorrhoeae p<0.001Conclusions: No evidence of risk compensation was observed in this trial.Trial registration number: NCT01539226.Funding Information
- International Partnership for Microbicides (IND # 110,659)
This publication has 38 references indexed in Scilit:
- Preexposure Prophylaxis for HIV Infection among African WomenThe New England Journal of Medicine, 2012
- Changes in condom use during a microbicide clinical trial in Pune, IndiaAIDS Care, 2011
- A qualitative study of sexual behavior change and risk compensation following adult male circumcision in urban SwazilandAIDS Care, 2011
- Prevalence and Incidence of HIV in a Rural Community-Based HIV Vaccine Preparedness Cohort in Masaka, UgandaPLOS ONE, 2011
- PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trialThe Lancet, 2010
- Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in WomenScience, 2010
- “When I Was Circumcised I Was Taught Certain Things”: Risk Compensation and Protective Sexual Behavior among Circumcised Men in Kisumu, KenyaPLOS ONE, 2010
- Change in condom and other barrier method use during and after an HIV prevention trial in ZimbabweJournal of the International AIDS Society, 2010
- Risk Compensation Is Not Associated with Male Circumcision in Kisumu, Kenya: A Multi-Faceted Assessment of Men Enrolled in a Randomized Controlled TrialPLOS ONE, 2008
- Tenofovir Disoproxil Fumarate for Prevention of HIV Infection in Women: A Phase 2, Double-Blind, Randomized, Placebo-Controlled TrialPLoS Clinical Trials, 2007