Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naive People With HIV
Open Access
- 1 October 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in Open Forum Infectious Diseases
- Vol. 7 (10), ofaa459
- https://doi.org/10.1093/ofid/ofaa459
Abstract
The NOD-like receptor protein family pyrin domain containing 3 (NLRP3) inflammasome, activated in the setting of HIV, contributes to pro-atherogenic inflammation. Among antriretroviral therapy-naive people with HIV (vs controls), levels of caspase-1-a key component of the NLRP3 inflammasome-were significantly increased. Six months of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate significantly decreased caspase-1 levels in association with CD4+/CD8+ ratio recovery.Funding Information
- National Institutes of Health (R01HL141132)
- National Heart, Lung, and Blood Institute (1K23HL147799-01)
- American Heart Association
- Harold Amos Medical Research Faculty Development Program
- Robert Wood Johnson Foundation
- Nutrition Obesity Research Center at Harvard (DK040561)
- National Center for Research Resources (8 UL 1TR000170, 1 UL 1TR001102)
This publication has 22 references indexed in Scilit:
- Caspase-1 Activity in CD4 T Cells Is Downregulated Following Antiretroviral Therapy for HIV-1 InfectionAIDS Research and Human Retroviruses, 2017
- Effects of Antiretroviral Therapy on Immune Function and Arterial Inflammation in Treatment-Naive Patients With Human Immunodeficiency Virus InfectionJAMA Cardiology, 2016
- Inflammasomes: mechanism of action, role in disease, and therapeuticsNature Medicine, 2015
- CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort studyThe Lancet HIV, 2015
- Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor–Based Initial Antiretroviral Therapy Among HIV-Infected IndividualsThe Journal of Infectious Diseases, 2015
- Risk of coronary heart disease in patients with HIV infectionNature Reviews Cardiology, 2014
- HIV-1 Infection Induces Interleukin-1β Production via TLR8 Protein-dependent and NLRP3 Inflammasome Mechanisms in Human MonocytesJournal of Biological Chemistry, 2014
- NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatinClinical Science, 2013
- HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived MacrophagesIntervirology, 2013
- Immunologic Basis of Cardiovascular Disease in HIV-Infected AdultsThe Journal of Infectious Diseases, 2012