Effect of oral tranexamic acid on erythema index in patients with melasma
- 30 October 2020
- journal article
- research article
- Published by Wiley in Australasian Journal of Dermatology
- Vol. 62 (2), 206-209
- https://doi.org/10.1111/ajd.13482
Abstract
Melasma is a common disorder of hyperpigmentation that presents a therapeutic challenge for clinical dermatologists. The pathogenesis is complex, but previous studies have demonstrated vascular proliferation is a key factor in the development of the classic hyperpigmented patches. Studies have revealed reduction of erythema by oral tranexamic acid; however, there has been no direct comparison to placebo. This 24‐week randomised placebo‐controlled trial demonstrates oral tranexamic acid may improve erythema in melasma. This mechanism of action may be the reason for the success of tranexamic acid in complex and difficult to treat melasma.Keywords
This publication has 10 references indexed in Scilit:
- Tranexamic Acid for Adults with Melasma: A Systematic Review and Meta-AnalysisBioMed Research International, 2018
- Oral Tranexamic Acid for the Treatment of Melasma: A ReviewDermatologic Surgery, 2018
- Melasma, a photoaging disorderPigment Cell & Melanoma Research, 2017
- Comparing the efficacy of topical hydroquinone 2% versus intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trialJournal of Dermatological Treatment, 2017
- Efficacy of functional microarray of microneedles combined with topical tranexamic acid for melasmaMedicine, 2017
- Interpretability of the Modified Melasma Area and Severity Index (mMASI)JAMA Dermatology, 2016
- Oral tranexamic acid (TA) in the treatment of melasma: A retrospective analysisJournal of the American Academy of Dermatology, 2016
- Oral tranexamic acid lightens refractory melasmaAustralasian Journal of Dermatology, 2016
- Treatment of Melasma With Oral Administration of Tranexamic AcidAesthetic Plastic Surgery, 2012
- Effect of tranexamic acid on melasma: a clinical trial with histological evaluationJournal of the European Academy of Dermatology and Venereology, 2012