Comprehensive Evaluation of Rhythm Monitoring Strategies in Screening for Atrial Fibrillation
Top Cited Papers
- 12 May 2020
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 141 (19), 1510-1522
- https://doi.org/10.1161/circulationaha.119.044407
Abstract
Background: Stroke is an increasing health problem world-wide. Atrial fibrillation (AF) is a major risk factor for stroke, and the attention towards AF screening is rising, while new monitoring-technologies emerge. We aimed to evaluate the performance of a large panel of screening strategies and to assess population characteristics associated with diagnostic yield. Methods: Persons with stroke risk factors but without AF were recruited from the general population to undergo screening with implantable loop recorder (ILR). New-onset AF lasting ≥6 min was adjudicated by senior cardiologists. After continuous monitoring for >3 years complete day-to-day heart rhythm datasets were reconstructed for every participant, including exact time of onset and termination of all AF episodes. Random sampling was applied to assess the sensitivity and negative predictive value (NPV) of screening with various simulated screening strategies compared to ILR. The yield across strategies and population subgroups was compared using non-parametric tests. Results: The rhythm datasets comprised 590 participants enduring a total of 659,758 days of continuous monitoring and 20,110 AF episodes. In this data, a single 10-sec ECG yielded a sensitivity (and NPV) of 1.5% (66%) for AF detection, increasing to 8.3% (67%) for twice-daily 30-sec ECGs during 14 days, and to 11% (68%), 13% (68%), 15% (69%), 21% (70%), and 34% (74%) for a single 24-h, 48-h, 72-h, 7-day, or 30-day continuous monitoring, respectively. AF detection further improved when subsequent screenings were performed, or when the same monitoring-duration was spread over several periods as compared to a single period (e.g. three 24-h monitorings vs. one 72-h monitoring), p2, or brain natriuretic peptide (NT-proBNP) ≥40 pmol/L, and among participants with underlying ≥24-h AF episodes compared to shorter AF, pConclusions: In screening for AF among participants with stroke risk factors, the diagnostic yield increased with duration, dispersion and number of screenings, although all strategies had low yield compared to ILR. The sensitivity was higher among participants who were older, males, or had higher NT-proBNP. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT02036450This publication has 42 references indexed in Scilit:
- Stepwise Screening of Atrial Fibrillation in a 75-Year-Old PopulationCirculation, 2013
- Pilot Randomized Trial of Outpatient Cardiac Monitoring After Cryptogenic StrokeStroke, 2013
- A Comprehensive Evaluation of Rhythm Monitoring Strategies for the Detection of Atrial Fibrillation RecurrenceCirculation, 2012
- Forecasting the Future of Cardiovascular Disease in the United StatesCirculation, 2011
- N-Terminal Pro-B-Type Natriuretic Peptide Is a Major Predictor of the Development of Atrial FibrillationCirculation, 2009
- Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trialBMJ, 2007
- Clinical Implications of Various Follow Up Strategies After Catheter Ablation of Atrial FibrillationPacing and Clinical Electrophysiology, 2007
- Comparison of continuous versus intermittent monitoring of atrial arrhythmiasHeart Rhythm, 2006
- Perception of Atrial Fibrillation Before and After Radiofrequency Catheter AblationCirculation, 2005
- Relationship between atrial tachyarrhythmias and symptomsHeart Rhythm, 2005