Itch in Chronic Wounds: Pathophysiology, Impact, and Management
Open Access
- 15 November 2019
- Vol. 6 (4), 112
- https://doi.org/10.3390/medicines6040112
Abstract
Background: The aims of this review are to analyze the current literature regarding the characteristics and pathophysiological mechanisms of itch in chronic wounds, to assess the impact on quality of life and delayed-healing, to focus on the best strategies of prevention and treatment, to highlight the importance of on-going research in order to fully understand the pathophysiology, and to improve the management of target therapies. Methods: A systematic literature review was performed using MEDLINE, PubMed, Embase, Scopus, ScienceDirect, and the Cochrane Library. We included a total of 11 articles written in English with relevant information on the pathophysiology of itch in chronic wounds and on management strategies. Results: Itch in chronic wounds was found to be correlated with xerosis, larger wound areas, necrotic tissue and amount of exudate, peripheral tissue edema, sclerosis, granulation tissue, contact dermatitis, and bacterial burden, as well as with lower quality of life. Conclusions: Although there are several aspecific pharmacological and non-pharmacological approaches, there appears to be no validated prevention or management strategy for itch in chronic wounds. Further studies are needed to clarify the association and pathophysiology of itch in chronic wounds, to evaluate the safety and efficacy of topical treatments on perilesional skin to reduce itch, to characterize multidimensional sensations of itch in chronic wounds, to identify specific cytokine and chemokine expressions that are correlated to a tailored-based approach, and to develop practical guidelines.Keywords
This publication has 16 references indexed in Scilit:
- Psychological management of wound pruritusJournal of Wound Care, 2014
- Wound pruritus: prevalence, aetiology and treatmentJournal of Wound Care, 2013
- Itch Characteristics in Five Dermatoses: Non-atopic Eczema, Atopic Dermatitis, Urticaria, Psoriasis and ScabiesActa Dermato-Venereologica, 2013
- A cross-sectional study of chronic wound-related pain and itching.2013
- Characteristics of Chronic Wounds that ItchAdvances in Skin & Wound Care, 2013
- ItchJournal of Wound, Ostomy & Continence Nursing, 2011
- The venous leg ulcer quality of life (VLU‐QoL) questionnaire: development and psychometric validationWound Repair and Regeneration, 2007
- Prevention and Treatment of Moisture-Associated Skin Damage (Maceration) in the Periwound SkinJournal of Wound, Ostomy & Continence Nursing, 2007
- Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of lifeJournal of the American Academy of Dermatology, 2005
- Measuring the impact of venous leg ulcers on quality of lifeJournal of Wound Care, 2005