Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients
Open Access
- 4 March 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Respiratory Research
- Vol. 21 (1), 1-10
- https://doi.org/10.1186/s12931-020-1323-4
Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations. Several aspects like persistence in smoking habit, continuous exacerbations, alpha-1-antitrypsin deficiency and inflammatory-immune response, are involved in the pathophysiology and progression of the disease. However, the role of natural killer (NK) cells remains controversial. Otherwise, human cytomegalovirus (HCMV) infection has been reported to induce an adaptive differentiation and expansion of an NK cell subset which carries the CD94/NKG2C receptor, which may contribute to an upset immune defense. For these reasons, our objective is to assess the distribution of NK cells and their subset in COPD patients and some of its phenotypes. Peripheral blood samples were obtained from 66 COPD patients. HCMV serology and the proportions of total NK cells and the NKG2C+ and NKG2A+ subsets were evaluated by flow cytometry. The NKG2C genotype was also assessed. Eighty-eight per cent of COPD patients were HCMV(+), and the proportions of total NK cells were higher in patients with severe-very severe airway obstruction than in those with only mild-moderate involvement. There were no differences in the proportions of NKG2C+ cells between controls and COPD, either among COPD patients classified by severity of the disease. However, the percentage of NKG2C+ cells were higher in COPD patients with frequent exacerbations than in occasional exacerbators, and higher in cases with reduced lean mass (Fat free mass index) than in those with normal nutritional status. These results suggest a relationship between levels of NKG2C+ cells in COPD patients and clinical variables closely linked to a poor/worse prognosis.Funding Information
- Sociedad Española de Neumología y Cirugía Torácica (2015)
- Conselleria d'Educació, Investigació, Cultura i Esport (SAF2013-49063-C2-1-R)
- MINECO Plan Estatal I+D Retos (SAF2014-54371, SAF2016-80363-C2-1-R)
- FUCAP
- Menarini
This publication has 58 references indexed in Scilit:
- Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary DiseaseJournal of Immunology Research, 2013
- Natural killer T cells in pulmonary disordersRespiratory Medicine, 2011
- Cytotoxic T cells expressing the co-stimulatory receptor NKG2 D are increased in cigarette smoking and COPDRespiratory Research, 2010
- Enhanced effector function of cytotoxic cells in the induced sputum of COPD patientsRespiratory Research, 2010
- Altered effector function of peripheral cytotoxic cells in COPDRespiratory Research, 2009
- Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like diseaseJCI Insight, 2009
- Immunobiology of Human Cytomegalovirus: from Bench to BedsideClinical Microbiology Reviews, 2009
- Immunology of asthma and chronic obstructive pulmonary diseaseNature Reviews Immunology, 2008
- Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysemaRespiratory Research, 2007
- Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in diseaseClinical and Experimental Immunology, 2007