Dynamics of Antibiotic Resistance of Streptococcus pneumoniae in France: A Pediatric Prospective Nasopharyngeal Carriage Study from 2001 to 2022
Open Access
- 6 June 2023
- journal article
- research article
- Published by MDPI AG in Antibiotics
- Vol. 12 (6), 1020
- https://doi.org/10.3390/antibiotics12061020
Abstract
Epidemiological surveillance of nasopharyngeal pneumococcal carriage is important for monitoring serotype distribution and antibiotic resistance, particularly before and after the implementation of pneumococcal conjugate vaccines (PCVs). With a prospective surveillance study in France, we aimed to analyze the dynamics of pneumococcal carriage, antibiotic susceptibility and serotype distribution in children aged 6 to 24 months who had acute otitis media between 2001 and 2022 with a focus on the late PCV13 period from May 2014 to July 2022. Trends were analyzed with segmented linear regression with autoregressive error. For the 17,136 children enrolled, overall pneumococcal carriage was stable during the study. During the late PCV13 period, the five most frequent serotypes were all non-PCV13 serotypes: 15B/C (14.3%), 23B (11.0%), 11A (9.6%), 15A (7.4%) and 35B (6.5%). During the same period, we observed a rebound of penicillin non-susceptibility (+0.15% per month, 95% confidence interval, +0.08 to 0.22, p < 0.001). Five serotypes accounted for 64.4% of the penicillin non-susceptible strains: 11A (17.5%), 35B (14.9%), 15A (13.9%), 15B/C (9.9%) and 19F (8.2%); non-PCV13/PCV15 accounted for <1%, and non-PCV15/PCV20 accounted for 28%. The next generation PCVs, particularly PCV20, may disrupt nasopharyngeal carriage and contribute to decreasing the rate of antibiotic resistance among pneumococci.Keywords
Funding Information
- Pfizer (NA)
This publication has 37 references indexed in Scilit:
- The 7-valent pneumococcal conjugate vaccine elicits cross-functional opsonophagocytic killing responses to Streptococcus pneumoniae serotype 6D in childrenBMC Infectious Diseases, 2013
- Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive DiseaseAmerican Journal of Epidemiology, 2013
- Impact of 13-valent Pneumococcal Conjugate Vaccine on Pneumococcal Nasopharyngeal Carriage in Children With Acute Otitis MediaThe Pediatric Infectious Disease Journal, 2012
- Association of Nasopharyngeal Bacterial Colonization during Upper Respiratory Tract Infection and the Development of Acute Otitis MediaClinical Infectious Diseases, 2008
- Acute Otitis Media in ChildrenPediatric Drugs, 2008
- Modeling the Association between Pneumococcal Carriage and Child-Care Center AttendanceClinical Infectious Diseases, 2005
- Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseThe Lancet Infectious Diseases, 2004
- Genetic Basis for the Structural Difference between Streptococcus pneumoniae Serotype 15B and 15C Capsular PolysaccharidesInfection and Immunity, 2003
- Relationship between Nasopharyngeal Colonization and the Development of Otitis Media in ChildrenThe Journal of Infectious Diseases, 1997
- On classifying otitis media as suppurative or nonsuppurative, with a suggested clinical schemaThe Journal of Pediatrics, 1987