Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis
Open Access
- 1 June 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 72 (11), 2025-2028
- https://doi.org/10.1093/cid/ciaa1011
Abstract
Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.Funding Information
- US Department of Health and Human Services
- National Cancer Institute (K23MH12286)
- National Institute of Mental Health (K23MH12286)
- National Institutes of Health (K23MH12286)
- National Institute of Allergy and Infectious Diseases (R01AI118575, R01AI122298, R01AI143340, 2R01AI098472)
- U.S. Department of Health and Human Services
This publication has 11 references indexed in Scilit:
- Acquisition of Multidrug-Resistant Human Immunodeficiency Virus Type 1 Infection in a Patient Taking Preexposure ProphylaxisClinical Infectious Diseases, 2018
- Seroconversion on preexposure prophylaxisAIDS, 2018
- Newly Acquired Infection With Multidrug-Resistant HIV-1 in a Patient Adherent to Preexposure ProphylaxisJAIDS Journal of Acquired Immune Deficiency Syndromes, 2017
- Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case reportThe Lancet HIV, 2017
- Multidrug-Resistant HIV-1 Infection despite Preexposure ProphylaxisThe New England Journal of Medicine, 2017
- Preexposure Prophylaxis for HIV Prevention in a Large Integrated Health Care System: Adherence, Renal Safety, and DiscontinuationJAIDS Journal of Acquired Immune Deficiency Syndromes, 2016
- HIV-1 Drug Resistance in the iPrEx Preexposure Prophylaxis TrialThe Journal of Infectious Diseases, 2014
- Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with MenScience Translational Medicine, 2012
- Protection against Rectal Transmission of an Emtricitabine-Resistant Simian/Human Immunodeficiency Virus SHIV162p3M184VMutant by Intermittent Prophylaxis with TruvadaJournal of Virology, 2011
- Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-Experienced Patients Are Missed by Standard Genotype AnalysisJournal of Clinical Microbiology, 2005