Early response assessment after CyberKnife stereotactic radiosurgery for symptomatic vertebral hemangioma by quantitative parameters from dynamic contrast-enhanced MRI
- 1 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Spine Journal
- Vol. 30 (10), 2867-2873
- https://doi.org/10.1007/s00586-021-06742-2
Abstract
Purpose The present study aimed to explore the value of DCE-MRI to evaluate the early efficacy of CyberKnife stereotactic radiosurgery in patients with symptomatic vertebral hemangioma (SVH). Methods A retrospective analysis of patients with spinal SVH who underwent CyberKnife stereotactic radiosurgery from January 2017 to August 2019 was performed. All patients underwent DCE-MRI before treatment and three months after treatment. The parameters included volume transfer constant (Ktrans), transfer rate constant (Kep), and extravascular extracellular space volume fraction (Ve). Results A total of 11 patients (11 lesions) were included. After treatment, six patients (54.5%) had a partial response, five patients (45.4%) had stable disease, and three patients (27.3%) presented with reossification. Ktrans and Kep decreased significantly in the third month after treatment (p = 0.003 and p = 0.026, respectively). ΔKtrans was −46.23% (range, −87.37 to −23.78%), and ΔKep was −36.18% (range, −85.62 to 94.40%). The change in Ve was not statistically significant (p = 0.213), and ΔVe was −28.01% (range, −58.24 to 54.76%). Conclusion DCE-MRI parameters Ktrans and Kep change significantly after CyberKnife stereotactic radiosurgery for SVH. Thus, DCE-MRI may be of value in determining the early efficacy of CyberKnife stereotactic radiosurgery.Keywords
Funding Information
- National Natural Science Foundation of China (81971578, 81701648)
- Key Clinical Projects of the Peking University Third Hospital (BYSY2018007)
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