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Successful use of IFN-γ for refractory systemic infection with Candida tropicalis in a child with AML and CARD9 mutation

Kleinschmidt Katharina, Troeger Anja, Foell Juergen, Jakob Marcus, Corbacioglu Selim

Abstract: Infectious complications remain major causes of treatment-related morbidity and mortality in children with acute myelogenous leukemia (AML) due to the intensive chemotherapeutic regimens needed to treat this disease. Invasive fungal infections (IFI) represent a particularly severe condition that affects 5% - 13% of AML patients with a persistently unacceptable mortality rate of 40%.
Keywords: children / treatment / AML / chemotherapeutic / Invasive / unacceptable / refractory / systemic / fungal

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