Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study
Top Cited Papers
Open Access
- 1 February 2021
- Vol. 70 (2), 251-260
- https://doi.org/10.1136/gutjnl-2019-320200
Abstract
Objectives To estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China. Design This multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group. Results Our cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively. Conclusion Among individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.Funding Information
- National Key R&D Program of China (2016YFC0901400, 2016YFC1302800)
This publication has 26 references indexed in Scilit:
- Long-Term Follow-Up of a Community Assignment, One-Time Endoscopic Screening Study of Esophageal Cancer in ChinaJournal of Clinical Oncology, 2015
- Impact of endoscopic screening on mortality reduction from gastric cancerWorld Journal of Gastroenterology, 2015
- Endoscopic Screening for Precancerous Lesions of the Esophagus in a High Risk Area in Northern Iran2014
- Cost-effectiveness Outcomes of the National Gastric Cancer Screening Program in South KoreaAsian Pacific Journal of Cancer Prevention, 2013
- Incidence rates in dynamic populationsInternational Journal of Epidemiology, 2012
- Colorectal-Cancer Incidence and Mortality with Screening Flexible SigmoidoscopyThe New England Journal of Medicine, 2012
- Endoscopic Findings in a Mass Screening Program for Gastric Cancer in a High Risk Region - Guilan Province of IranAsian Pacific Journal of Cancer Prevention, 2012
- Decreased death from gastric cancer by endoscopic screening: Association with a population-based cancer registryScandinavian Journal of Gastroenterology, 2008
- Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative studyStatistics in Medicine, 2004
- Long-term results of operation for 420 patients with early squamous cell esophageal carcinoma discovered by screeningThe Annals of Thoracic Surgery, 2004