The acute toxicity study GIZH-290 in mice
Open Access
- 25 June 2021
- journal article
- Published by Publishing House OKI in Pharmacokinetics and Pharmacodynamics
- No. 4,p. 41-47
- https://doi.org/10.37489/2587-7836-2020-4-41-46
Abstract
Acute toxicity testing is a commonly accepted procedure for preclinical testing of the safety of potential drugs. The compound GIZh-290, which is a derivative of 4-phenylpyrrolidone– 2,6 - dimethylanilide (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid and has a nootropic and anticonvulsant effect, was studied. The results obtained after a single oral and intraperitoneal administration to mice allow us to attribute GIZH-290 to the 4th class of toxicity – "lowtoxic substances". The study revealed the neurotoxic effects of GIZH-290, which may be due to the main pharmacological activity of the compound used in sublethal doses.Keywords
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