Systemic Inflammation, Oxidative Damage to Nucleic Acids, and Metabolic Syndrome in the Pathogenesis of Psoriasis
Open Access
- 25 October 2017
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 18 (11), 2238
- https://doi.org/10.3390/ijms18112238
Abstract
In the pathogenesis of psoriasis, systemic inflammation and oxidative stress play mutual roles interrelated with metabolic syndrome (MetS). This study aims to map the selected markers of inflammation (C-reactive protein (CRP)), oxidative damage to nucleic acids (DNA/RNA damage; 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), and the parameters of MetS (waist circumference, fasting glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, diastolic and systolic blood pressure) in a group of 37 patients with psoriasis (62% of MetS) and in 43 healthy controls (42% of MetS). Levels of CRP, DNA/RNA damage, fasting glucose, and triglycerides were significantly elevated in patients. MetS in conjunction with psoriasis was associated with high levels of CRP, significantly higher than in control subjects without MetS. Patients with MetS exhibited further DNA/RNA damage, which was significantly higher in comparison with the control group. Our study supports the independent role of psoriasis and MetS in the increase of CRP and DNA/RNA damage. The psoriasis contributes to an increase in the levels of both effects more significantly than MetS. The psoriasis also diminished the relationship between CRP and oxidative damage to nucleic acids existent in controls.This publication has 36 references indexed in Scilit:
- C‐reactive protein in psoriasis: a review of the literatureJournal of the European Academy of Dermatology and Venereology, 2013
- Prevalence of Metabolic Syndrome in Patients with Psoriasis: A Population-Based Study in the United KingdomJournal of Investigative Dermatology, 2012
- Psoriasis and metabolic syndromeThe Journal of Dermatology, 2011
- Prevalence of the Metabolic Syndrome in PsoriasisArchives of Dermatology, 2011
- C‐reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapyJournal of the European Academy of Dermatology and Venereology, 2010
- Psoriasis and the metabolic syndromeDermatologic Therapy, 2010
- The lipid profile in psoriasis: a controlled studyJournal of the European Academy of Dermatology and Venereology, 2007
- Prevalence of cardiovascular risk factors in patients with psoriasisJournal of the American Academy of Dermatology, 2006
- Psoriasis is associated with lipid abnormalities at the onset of skin diseaseJournal of the American Academy of Dermatology, 2006
- C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular EventsCirculation, 2003