Emerging Role of Mitochondrial Function Enhancement in Mesenchymal Stem Cell Therapy

Abstract

The impact of inflammatory environments on the impaired features of MSCs, such as loss of homeostasis and stem cell senescence, still remains unclear. In the paper titled “MIT-001 Restores Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization”, Yu et al., investigated the phenotypes of MSCs exposed to pro-inflammatory cytokines TNF-α and IFN-γ. They further tested whether the exposed MSCs are protected from senescence by MIT-001, a novel necrosis inhibitor and an anti-inflammatory molecule