Depolarization metric spaces for biological tissues classification
Open Access
- 1 August 2020
- journal article
- research article
- Published by Wiley in Journal of Biophotonics
- Vol. 13 (8), e202000083
- https://doi.org/10.1002/jbio.202000083
Abstract
Classification of tissues is an important problem in biomedicine. An efficient tissue classification protocol allows, for instance, the guided-recognition of structures through treated images or discriminating between healthy and unhealthy regions (e.g., early detection of cancer). In this framework, we study the potential of some polarimetric metrics, the so-called depolarization spaces, for the classification of biological tissues. The analysis is performed using 120 biological ex vivo samples of three different tissues types. Based on these data collection, we provide for the first time a comparison between these depolarization spaces, as well as with most commonly used depolarization metrics, in terms of biological samples discrimination. The results illustrate the way to determine the set of depolarization metrics which optimizes tissue classification efficiencies. In that sense, the results show the interest of the method which is general, and which can be applied to study multiple types of biological samples, including of course human tissues. The latter can be useful for instance, to improve and to boost applications related to optical biopsy.Funding Information
- Ministerio de Economía y Competitividad (Fondos FEDER, RTI2018‐097107‐B‐C31)
This publication has 48 references indexed in Scilit:
- Polarimetric Imaging for Cancer Diagnosis and StagingOptics and Photonics News, 2012
- Fiber Types in Mammalian Skeletal MusclesPhysiological Reviews, 2011
- Invariant indices of polarimetric purity: Generalized indices of purity for n×n covariance matricesOptics Communications, 2011
- Tendon: Biology, Biomechanics, Repair, Growth Factors, and Evolving Treatment OptionsThe Journal of Hand Surgery, 2008
- Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringenceJournal of Biomedical Optics, 2008
- Regularized linear discriminant analysis and its application in microarraysBiostatistics, 2006
- Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetryJournal of Biomedical Optics, 2004
- Building Collagen Molecules, Fibrils, and Suprafibrillar StructuresJournal of Structural Biology, 2002
- Depolarization and Polarization Indices of an Optical SystemOptica Acta: International Journal of Optics, 1986
- The Multicomposite Structure of TendonConnective Tissue Research, 1978