T Cell Phenotyping in Individuals Hospitalized with COVID-19
- 1 April 2021
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 206 (7), 1478-1482
- https://doi.org/10.4049/jimmunol.2001034
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic. Cytokine release syndrome occurring in a minority of SARS-CoV-2 infections is associated with severe disease and high mortality. We profiled the composition, activation, and proliferation of T cells in 20 patients with severe or critical COVID-19 and 40 matched healthy controls by flow cytometry. Unsupervised hierarchical cluster analysis based on 18 T cell subsets resulted in separation of healthy controls and COVID-19 patients. Compared to healthy controls, patients suffering from severe and critical COVID-19 had increased frequencies of activated and proliferating CD38(+) Ki67(+) CD4(+) and CD8(+) T cells, suggesting active antiviral T cell defense. Frequencies of CD38(+) Ki67(+) Th1 and CD4(+) cells correlated negatively with plasma IL-6. Thus, our data suggest that patients suffering from COVID-19 have a distinct T cell composition that is potentially modulated by IL-6.This publication has 39 references indexed in Scilit:
- TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infectionScientific Reports, 2015
- Current concepts in the diagnosis and management of cytokine release syndromeBlood, 2014
- Standardizing immunophenotyping for the Human Immunology ProjectNature Reviews Immunology, 2012
- Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral InfectionScience, 2011
- IL‐6: Regulator of Treg/Th17 balanceEuropean Journal of Immunology, 2010
- Loss of Naive T Cells and Repertoire Constriction Predict Poor Response to Vaccination in Old PrimatesThe Journal of Immunology, 2010
- Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly PersonsJournal of Virology, 2005
- CD38 Expression on CD8+ T Cells as a Prognostic Marker in Vertically HIV-Infected Pediatric PatientsPediatric Research, 2002
- CD8+ lymphocyte phenotype and cytokine production in long-term non-progressor and in progressor patients with HIV-1 infectionClinical and Experimental Immunology, 1996
- Expression of CD28 on CD8+ and CD4+ Lymphocytes During HIV InfectionScandinavian Journal of Immunology, 1994