Evaluating Neutrophil Gelatinase-Associated Lipocalin as an Early Marker of Acute Kidney Injury in Critically Ill Patients
Open Access
- 11 August 2021
- journal article
- Published by Briefland in Nephro-Urology Monthly
- Vol. 13 (3)
- https://doi.org/10.5812/numonthly.96351
Abstract
Background: Detecting significant renal injury in an accurate and timely manner in acute kidney injury (AKI) patients who are critically ill remains controversial. Serum creatinine (Cr) is an important marker of kidney function in clinical practice, and its limitations are well known. Objectives: This study aimed to evaluate neutrophil gelatinase-associated lipocalin (NGAL) as a marker of the early development of AKI in critically ill AKI patients. Methods: This prospective study was carried out at JSS Hospital, Mysuru, India. The diagnosis and staging of AKI was done according to the RIFLE criteria. Results: A total of 53 critically ill patients were enrolled in this study. During Intensive Care Unit (ICU) stay, 34 (64.2%) patients developed AKI according to RIFLE criteria. Serum NGAL levels assessed on admission were an appropriate predictor of AKI com-pared to serum Cr. Serum NGAL levels also showed a significant elevation among AKI patients than non-AKI cases. The mean levels for AKI patients at 0, 4, and 8 hours were 870.53, 1074.9, and 1090, respectively. Meanwhile, the mean levels for non-AKI patients at 0, 4, and 8 hours were 337, 307, and 292. Conclusions: Measuring serum NGAL on admission is useful in the early diagnosis of AKI com-pared to serum Cr.Keywords
This publication has 13 references indexed in Scilit:
- Plasma neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in adult critically ill patients: A prospective studyJournal of Critical Care, 2010
- Long-Term Risk of Mortality and Acute Kidney Injury During Hospitalization After Major SurgeryAnnals of Surgery, 2009
- Development and Validation of an Acute Kidney Injury Risk Index for Patients Undergoing General SurgeryAnesthesiology, 2009
- Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patientscclm, 2009
- Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shockCritical Care Medicine, 2008
- Dual Action of Neutrophil Gelatinase–Associated LipocalinJournal of the American Society of Nephrology, 2007
- Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epitheliaCurrent Opinion in Nephrology and Hypertension, 2006
- Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgeryThe Lancet, 2005
- Expression of Neutrophil Gelatinase-associated Lipocalin Regulates Epithelial Morphogenesis in VitroOnline Journal of Public Health Informatics, 2005
- Studies of the release and turnover of a human neutrophil lipocalinScandinavian Journal of Clinical and Laboratory Investigation, 1995